Attempts to Understand Metastasis Formation II: Regulatory Factors

ISBN-13: 9783642646980 / Angielski / Miękka / 2011 / 288 str.

Ursula G. Nthert; Walter Birchmeier

Opis

Within the last decade the molecular biology of tumor models has revealed the identification of several metastasis- related molecules. These volumes attempt to review the most recent approaches of their mechanisms, regulation and way to treat their malignant alterations. The first volume covers the presentation of proteases and inhibitors and their role in invasion of tumor cells, also cell adhesion molecules and their interaction with the extracellular matrix. In the second volume the regulation of tumor progression and angiogenesis by cytokines, growth factors and motility factors is outlined. The third volume deals with detection of micrometastases and therapeutic approaches, such as immunotherapy, gene therapy, chemotherapy and surgical strategies to combat metastatic spread.

Spis treści

List of Contents.- Regulation of Tumor Angiogenesis by Organ-Specific Cytokines.- Cytokine-Mediated Tumor-Endothelial Cell Interaction in Metastasis.- Angiogenesis-Regulating Cytokines: Activities and Interactions.- Adhesion Molecules and Tumor Cell-Vasculature Interactions: Modulation by Bioactive Lipid Molecules.- Brain Metastasis: Role of Trophic, Autocrine, and Paracrine Factors in Tumor Invasion and Colonization of the Central Nervous System.- Epithelial Differentiation and the Control of Metastasis in Carcinomas.- Regulation of Autocrine Motility Factor Receptor Expression in Tumor Cell Locomotion and Metastasis.- Metastasis-Related mts 1 Gene.- Alterations in Cell Cycle Control During Tumor Progression; Effects on Apoptosis and the Response to Therapeutic Agents.- Differential Gene Expression in Tumor Metastasis: Nm23.- NM23/Nucleoside Diphosphate Kinase as a Transcriptional Activator of c-myc.- Role of Tiam 1 in Rac-Mediated Signal Transduction Pathways.- Influence of c-myc on the Progession of Human Breast Cancer.