Assessment of the Effect of Copper Complex on Autophagy in TNBC cells

ISBN-13: 9783330017634 / Angielski / Miękka / 2018 / 136 str.

Eman Salah El-Shafey

Opis

Autophagy is a well-maintained process by which cells recycle intracellular materials to keep up homeostasis in various cellular settings. However, autophagy is a defensive mechanism that maintains cell survival under antagonistic conditions, the induction of autophagic process may substantially lead to cell death. The conflicting role of autophagy including allowing cell survival or promoting cell death could have troublesome impact on the efficiency of chemotherapeutic agents . The, current interest in copper complexes e.g., copper (I)- originated from their expanded spectrum of activity as antimicrobial, antiviral, anti-inflammatory, antitumor agents. Copper complexes frequently targeted apoptosis as a mechanism of cell death. However, the clarification of other mechanisms involved in the anti-proliferative activity of copper (I)-complexes (autophagy) may facilitate the generation of new era of copper drug

O autorze

El-Shafey, Eman Salah
Eman Salah El-Shafey is PhD post research fellow, Department of chemistry, Biochemistry specialization-faculty of science Damietta; Egypt. She received BSc (chemistry/biochemistry) from Mansoura University, MSc in biochemistry and PhD in biochemistry from Damietta University. She is interested in studying of Biochemistry and Cell Biology.