1. Foundations of Multi-Modal Analgesia 2. Importance of Multi-Modal Pain Management 3. Physiology of Pain 4. Barriers to Effective Pain Management 5. Introduction to Pain Assessment 6. Pain Assessment in Cognitively Intact Adults 7. Pain Assessment in Non-Verbal or Cognitively Impaired 8. Assess Factors Affecting and Affected by Pain 9. Basic Concepts of Analgesic Administration 10. Non-Opioid Analgesics 11. Opioids 12. Common Opioid Related Adverse Effects 13. Preventing Opioid Induced Advancing Sedation and Respiratory Depression 14. Opioid Use Disorder 15. Co-Analgesics 16. Topical Analgesia 17. Patient Controlled Analgesia 18. Regional and Intraspinal Approaches 19. Interventional Approaches 20. Exercise and Movement 21. Distraction and Relaxation 22. Cognitive Behavioral and Psychotherapeutic Interventions as a Component of Multimodal Analgesic Pain Management 23. Energy Therapies as Components of Multimodal Analgesic Pain Management 24. Manual Therapies for Pain Management 25. Spirituality and Meditation for Pain Management 26. Botanicals and Herbs for Pain Management 27. Other Non-Pharmacologic Interventions For Pain Management 28. Improving Institutional Commitment for Effective Multimodal Pain Management Ann Quinlan Colwell, Sue Ballato, Gregory Scott Firestone, and Eva Pittman Terminology Appendix