Assessment and Management of Hepatobiliary Disease

ISBN-13: 9783642726330 / Angielski / Miękka / 2011 / 452 str.

Lajos Okolicsanyi; Geza Csomos; Gaetano Crepaldi

Opis

The contributions to this volume cover all aspects of the assessment and management of hepatobiliary disease. The focal points of the book consist of three state-of-the-art summaries. The first of these deals with the highly topical problem of liver transplants from the point of view of patient selection. The second considers drug-induced liver injury in view of the fact that the liver is the main metabolic site for a number of drugs. The final summary deals with liver and aging: it asks whether the liver follows the aging process of the host organisms and whether the liver of aged liver transplant candidate donors could be suitable for grafting. Aside from these topics, the volume presents basic research on hepatic transport mechanisms, intrahepatic cholestasis and gall-stone disease, which serves as a background for the topics more specifically concerning the assessment of liver function. Much of the book is then devoted to the management of the commonest forms of liver diseases and their complications, such as chronic active hepatitis, liver cirrhosis, portal hypertension, hepatic encephalopathy, hepatorenal syndrome, and ascites.

Spis treści

Hepatic Transport Mechanisms, Intrahepatic Cholestasis and Gallstone Disease.- Liver Transplantation: State of the Art.- Mathematical Models for the Study of Liver Metabolism.- Mechanisms of Hepatic Fatty Acid Uptake.- Vesicular Transport of Fluid Phase Markers by Hepatocytes.- The Hepatic Uptake of Organic Anions: an Overview.- Mechanisms of Transport of Tauroconjugated Bile Acids in the Hepatocyte: Functional Significance.- Determinants of Biliary Cholesterol Secretion.- The Enterohepatic Circulation of Sulfated and Nonsulfated Bile Acids.- Esterogens and Bile Secretion.- Transport of UDPG in Vitro and Reversal of Ethanol-Induced Effects.- Associated Factors in Gallstone Disease.- Epidemiology of Gallstone Disease in Hungary.- The Role of the Gallbladder in Cholesterol Gallstone Pathogenesis.- Mechanism of Gallstone Formation in Obese Subjects.- Medical Treatment of Cholesterol Gallstones: Present and Future.- Bile Acid Treatment of Cholesterol Gallstones: A Reappraisal.- Biliary Lipid Composition after Endoscopic Sphincterotomy in Postcholecystectomy Patients: Effect of Short-Term Ursodeoxycholic Acid Administration.- Concluding Remarks.- Assessment of Liver Function.- Drug-Induced Liver Injury.- Biochemical Liver Tests: Recent Developments and Challenges.- Should Serum Bile Acid Determinations be performed Routinely in Patients with Liver Disease?.- Clinical Significance of Serum Bilirubins: Recent Advances.- Enzyme Pattern Changes in Preneoplastic and Neoplastic Lesions of the Liver.- The Value of Quantitation of Liver Function.- Quantitation of Liver Function: Antipyrine Metabolism, an Update.- Antipyrine Clearance: Evaluation of Simplified Methods in Chronic Liver Diseases.- Preoperative Care of Adult Patients Chosen for Liver Transplantation.- Assessment of Liver Function Before and After Liver Transplantation.- Hormones and Liver: Some Aspects of the Problem.- Effects of Thyroid Hormone Administration and of Thyroidectomy on the Metabolism of Bilirubin in Rats.- Comparison of Some Parameters of the Drug-Metabolizing Enzyme System and Liver Function Tests in Different Hepatic Diseases.- Interaction of Ethanol with Hepatic Drug Metabolism.- Antioxidant and Immunomodulant Effect of Hepatoprotective Drugs.- Stimulating Influence of a Flavonolignane Derivative on Proliferation, RNA Synthesis and Protein Synthesis in Liver Cells.- Renal Functional Impairment in Cirrhosis.- Pathophysiology of Cirrhotic Ascites.- Treatment of Ascites.- Low-Sodium Diet in the Management of Ascites in the Cirrhotic Patient.- Treatment of Refractory Ascites by Concentrated Ascitic Fluid Reinfusion.- Concluding Remarks.- Management of Liver Disease.- Liver and Aging.- Prognosis of Advanced Liver Disease.- Virus and Host Factors in the Evolution of Chronic Hepatitis Type B: Choice of Treatment.- Antiviral Treatment of Chronic Hepatitis.- Autoimmune Hepatitis: Diagnosis and Treatment.- Serum ?2-microglobulin and Anti- ?2m Antibodies in Chronic Liver Disease.- Treatment of Liver Cirrhosis.- Drug Therapy for Alcoholic Liver Disease.- Silymarin Treatment in Patients with Cirrhosis of the Liver—A Prospective Study.- Protein Malnutrition in Chronic Liver Disease: Corrective Measures.- The Management of Primary Biliary Cirrhosis.- Impaired Calcitonin Response to Intravenous Calcium Load in Primary Biliary Cirrhosis.- Prevention of Upper Gastrointestinal Bleeding in Cirrhotic Patients.- Prophylactic Treatment of First Variceal Bleeding in Cirrhotics with Nadolol or Ranitidine: A Prospective Randomized Study.- Hemodynamic and Clinical Evaluation of Nadolol in the Treatment of Portal Hypertension in Patients with Cirrhosis.- The GABA Hypothesis of the Pathogenesis of Hepatic Encephalopathy: Current Status.- Lactitol in the Prevention of Recurrent Hepatic Encephalopathy in Shunted Cirrhotic Patients. Preliminary Results of a Controlled Trial.- Concluding Remarks.