Artificial Oxygen Carrier: Its Front Line

ISBN-13: 9784431220749 / Angielski / Twarda / 2004 / 280 str.

K. Kobayashi; E. Tsuchida; Hirohisa Horinouchi

Opis

While a reliable supply of donated blood is vital in modern medicine, it remains the case that blood transfusion comes with its own problems, such as infectious diseases, immunological adverse reactions, and difficulties with long-term storage and transportation of blood components. With a view to solving these problems, developing a suitable blood substitute has been a major goal for decades. Artificial Oxygen Carrier: Its Front Line is a compilation of reports on the concepts behind artificial oxygen carriers, as well as the new discoveries in the field that were presented during the 13th Keio International Symposium for Life Science and Medicine. This volume describes valuable topics, including artificial red blood cells, modified haemoglobin, perfluorocarbons, and haemoglobin vesicles. It explains cutting-edge developments in artificial oxygen carrier research and will be a valuable resource to all concerned with the field.

Spis treści

Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes.- Red Blood Cell Substitutes: Past, Present, and Future.- Inhaled Nitric Oxide: Update 2003.- The Role of p50 in Tissue Oxygen Delivery by Cell-Free Oxygen Carriers.- Repetitive Administration of Hemoglobin Raffimer in Experimental Models and Clinical Applications.- Oxygen Gradients In Vivo Seen by a High Oxygen Affinity HB Polymer.- Oxygen Partition Between Microvessels and Tissue: Significance for the Design of Blood Substitutes.- Endothelial Cell Response to Hemoglobin Based Oxygen Carriers. Is the Attenuation of Pathological Reactions Possible?.- The Development of a Second-Generation, Designer, Recombinant Hemoglobin.- Hemoglobin-Vesicles (HbV) as Artificial Oxygen Carriers.- Successful Ex Vivo Normothermic Liver Perfusion with Purely Artificial Products Using Artificial Blood.- Effect of Hemoglobin-Based Blood Substitutes on Nitric Oxide Transport: Mathematical Models.- New Strategy for the Preparation of NO-Treated Red Blood Cells as a Blood Substitute.- Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme.- Micromechanical Properties of Newly Developed Polyelectrolyte Microcapsules (PEMC).- Intravascular Microbubbles: An Ultra-Effective Means of Transporting Oxygen.- Oxygen-Dependent and Oxygen-Independent Effects of Perftoran.- State of the Art and Challenges in Blood Substitutes Research: A Case Study on Perfluorocarbon-Based Oxygen Carriers.- Semifluorinated Alkanes as Stabilizing Agents of Fluorocarbon Emulsions.- Possible Role of Artificial Oxygen Carriers in Shock and Trauma.- Clinical Needs for Artificial Oxygen Carriers in Anaesthesia.- Studies on Red Cell Substitutes in Japan and Future Perspectives.