Arthritis: Pathophysiology, Prevention, and Therapeutics

ISBN-13: 9780367382872 / Angielski / Miękka / 2019 / 608 str.

Debasis Bagchi; Hiroyoshi Moriyama; Siba P. Raychaudhuri

Opis

An overall analysis of available arthritis treatments, including osteo- and rheumatoid arthritis, this book covers pathophysiology, traditional medicine, alternative therapies, and lifestyle changes. It focuses on treatment regimens, including synthetic drugs, their safety and toxicity; natural and herbal products; healthy foods; and non pharmacologic interventions such as acupuncture and psychosocial management. With numerous tables, figures, and charts, it examines the association of arthritis in obesity, hypertension, and cardiovascular disease and offers extensive research on natural products as well as synthetic drugs such as COX-2 inhibitors.

Spis treści

INTRODUCTION: Epidemiology of Arthritic Disorders. PATHOPHYSIOLOGY: An Overview on Rheumatologic Disorders. Osteoarthritis: Disease Pathophysiology. Biomarkers of Osteoarthritis. Rheumatoid Arthritis: Disease Pathophysiology. Inflammatory and Biomarkers in Patients with Rheumatoid Arthritis: Effects of Tumor. Necrosis Factor-alpha Blockade. Regulation of Osteoarthritis Development by Wnt-beta-catenin Signaling through the Endochondral Ossification Process. CONSEQUENCES: Arthritis, Obesity, Increased Cardiovascular Risk and Disability. ANTI-ARTHRITIC DRUGS: An Overview: Use of Anti-arthritic drugs and update on drug development coupled with DDS. COX-2 Inhibitors and Non-steroidal Anti-Inflammatory Drugs (Ibuprofen, phenylbutazone, naproxane, Maloxcan, Indomethacin). Celebrex and Vioxx. An Overview on Biologics for Arthritic Diseases. Topical Applications for Pain and Arthritic Diseases. Hyaluronic Acid. NATURAL THERAPEUTIC INTERVENTIONS: An Overview on Natural Therapeutic Interventions and Role of Physical Exercise. Glucosamine and Chondroitin: An Overview. Methylsulfonylmethane (MSM). S-Adenosyl-L-methlonine (SAMe). Undenatured type II Collagen (UC-II). Curcumin and Turmeric. Boswellia serrata, Indian Frankincense and 5-Loxin. Efficacy of Selected Oils including Fish Oil, Flaxseed (Linum usitatissimum), Omega-3 and Omega-6 Fatty Acids, y Linolenic Acid, Black Currant Oil, Borage Oil and Evening Primrose Oil in Arthritic Diseases. Avacado Soybean Unsaponifiables. Bromelain and Ananas comosus. Zingiber officinale (Ginger) and Olive Leaves. Cat's Claw, Devil's Claw, Stinging Nettle and Urtica diocia. Dehydroepiandrosterone (DHEA), Calcium and Vitamin D. Red pepper, Capsaicin, Thunder God Vine and Tripterygium wilfordii. Shark Cartilage. ORTHOPEDIC APPROACH: An Overview on Orthopedic Approach (Knee Replacement) in Arthriti

O autorze

Debasis Baghchi, Ph.D., FACN, CNS, MAIChE, works within the Department of Pharmacy Sciences at University of Houston College of Pharmacy.

Hiroyoshi Moriyama is Founder and Owner of MTI, Inc., a research and development company aimed at producing nutraceutical and cosmeceutical ingredients.