Arterial Chemoreceptors: Cell to System

ISBN-13: 9781461360995 / Angielski / Miękka / 2012 / 400 str.

Ronan G. O'Regan; Philip Nolan; Daniel S. McQueen

Opis

The International Society for Arterial Chemoreception (ISAC) was founded in August 1988 during the 9th International Symposium on Arterial Chemoreception which was held at Park City, Utah, USA. ISAC was established with the aim of providing a framework to support the increasing number of investigators from a wide variety of disciplines (anatomists, pathologists, respiratory physiologists and clinicians, high altitude physiologists, biochemists, biophysicists, physiologists and pharmacologists) who share a common interest in arterial chemoreception. ISAC took over the co-ordination of the international chemoreceptor meetings, with the membership deciding the venue for forthcoming meetings. During the Park City symposium Dublin was selected to host the 1993 meeting, under the Presidency of Professor Ronan O'Regan. The 12th International Meeting on Arterial Chemoreception, which was held in Dublin in August 1993, was acclaimed as a great success by all those present. The delegates not only shared in a wide-ranging feast of chemoreceptor based science, they had plenty of opportunity during the meeting for renewing acquaintances and establishing new friendships. The location for the meeting at University College Dublin's modem Belfield campus helped to promote such interaction, and the social programme was outstanding.

Spis treści

Eric Neil: An Appreciation.- International Meetings on Chemoreceptors: Historical Perspectives.- Oxygen Sensing in the Carotid Body: Ideas and Models.- Ionic Channels in Type I Carotid Body Cells.- Role of Intracellular pH and [Ca2+]iin Acid Chemoreception in Type I Cells of the Carotid Body.- Neurotransmitters in the Carotid Body.- Reflexes Arising from the Arterial Chemoreceptors.- Central Integration of Chemoreceptor Afferent Activity.- Chemoreceptor Function in the Fetus and Neonate.- The Role of Arterial Chemoreceptors in Ventilatory Acclimatization to Hypoxia.- Chemosensitivity from the Lungs of Vertebrates.- Heymans’ Visit to Dublin to Review “Buffer” Nerve Experiments.- A Belated Centennial Tribute to Corneille Heymans.- Glomera that are not Chemosensitive.- Electrotonic Coupling Between Carotid Body Glomus Cells.- CO-binding Chromophores in Oxygen Chemoreception in the Carotid Body.- Actions of Nicotinic Agonists on Isolated Type I Cells of the Neonatal Rat Carotid Body.- Ca2+-Activated K+-Channels from Isolated Type I Carotid Body Cells of the Neonatal Rat.- Culturing Carotid Body Cells of Adult Cats.- Plasticity in Cultured Arterial Chemoreceptors: Effects of Chronic Hypoxia and Cyclic AMP Analogs.- Carotid Body Chemoreception: Role of Extracellular Ca2+.- Cytosolic Calcium in Isolated Type I Cells of The Adult Rabbit Carotid Body: Effects of Hypoxia, Cyanide and Changes in Intracellular pH.- Characterization of Membrane Currents in Pulmonary Neuroepithelial Bodies: Hypoxia-Sensitive Airway Chemoreceptors.- Ionic Currents on Endothelial Cells of Rat Brain Capillaries.- Urokinase and its Receptor: Markers of Malignancy?.- Electrochemical Measurement of Rapid Dopamine Release in Perfused Cat Carotid Body during Onset of Hypoxia.- Hypoxia-Induced Catecholamine Release from Rat Carotid Body, In Vitro, during Maturation and following Chronic Hypoxia.- Assessment of Na+ Channel Involvement in the Release of Catecholamines from Chemoreceptor Cells of the Carotid Body.- Activation of GTP-binding Proteins by Aluminum Fluoride Modulates Catecholamine Release in the Rabbit Carotid Body.- Catecholamines in the Rabbit Carotid Body: Content And Secretion.- Cholinergic Aspects of Carotid Body Chemotransduction.- Low PO2 Dependency of Neutral Endopeptidase and Acetylcholinesterase Activities of the Rat Carotid Body.- Nitric Oxide Synthase Occurs in Neurons and Nerve Fibers of the Carotid Body.- NO Mimics O2 in the Carotid Body Chemoreception.- Mechanisms of Carotid Body Inhibition.- Proportional Sensitivity of Arterial Chemoreceptors to CO2.- Effects of Expiratory Duration on Chemoreceptor Oscillations.- Effects of Intravenous Infusions of KCl and Lactic Acid On Chemoreceptor Discharge In Anaesthetized Cats.- The Effect of Intravenous Infusion of Lactic Acid on Carotid Chemoreceptor Discharge in Anaesthetized Cats Ventilated with Room Air or 100% O2.- The Carotid Bodies as Thermosensors: Experiments in vitro and in situ, and Importance for Ventilatory Regulation.- Inhibition of Ventilation by Carotid Body Hypocapnia during Sleep.- Metabolic Acid-Base Status and the Role of Carotid Chemoreceptors in Hyperoxic Breathing.- Ventilatory Responses to Histotoxic Chemostimulation in Hypoxia Adapted Rats.- Chemoreflex Sensitization Augments Sympathetic Vasomotor Outflow in Awake Humans.- Carotid Chemoreceptor Control of Vascular Resistance in Resting and Contracting Skeletal Muscle.- Substance P Inhibits Ventilation in the Goat.- Central Glutamate and Substance-P in the Hypoxic Ventilatory Response.- Carotid Chemoreceptor Activity and Heart Rate Responsiveness to Hypoxia after Inhibition of Nitric Oxide Synthase.- Effects of Endothelins on Respiration and Arterial Chemoreceptor Activity in Anaesthetised Rats.- Changes in Blood Glucose Concentration in the Carotid Body Modify Brain Glucose Retention.- Is the Second Carotid Body Redundant?.- Activity of Cardiac Vagal Preganglionic Neurones during the Pulmonary Chemoreflex in the Anaesthetized Cat.- Trophic Regulation of Carotid Body Afferent Development.- Carotid Body Dopamine Response to Acute Hypoxia in Developing Rabbits.- Attenuation of the Hypoxic Ventilatory Response in Awake Rabbit Pups; Possible Role Of Dopamine.- D2-Dopamine Receptor mRNA in the Carotid Body and Petrosal Ganglia in the Developing Cat.- The Role of Endogenous Dopamine as an Inhibitory Neuromodulator in Neonatal and Adult Carotid Bodies.- Intracellular Calcium Responses to Hypoxia and Cyanide in Cultured Type I Cells from Newborn and Adult Rabbits.- Effects of Acetazolamide on the Time Course of the CO2 Response of Carotid Body in the Newborn Kitten.- Cardiovascular Responses to Hypoxia in Developing Swine.- Fetal Reflexes in Chronic Hypoxaemia.- Is the Rapid and Intense Peripheral Vasoconstriction Occurring during Acute Hypoxaemia in the Llama Fetus an Arterial Chemoreflex?.- Is the Ventilatory Decline Seen in Newborns during Hypoxaemia Centrally Mediated?.- Postmortem Changes in the Human Carotid Body.- Effects of Various Diseases upon the Structure of the Human Carotid Body.- Modification of the Rabbit Carotid Body Type I Cell Mitochondria by High Altitude Exposure and the Effects of Dracocephalum Heterophyllum.- Breathing Frequency and Tidal Volume are Independently Controlled in Garter Snakes: The Role of CO2-Rise Time.- Effects of Chronic Hypoxia on Rat Carotid Body and Toad Carotid Labyrinth Glomus Cells.- The Stimulus Modality of the Hypoxic Ventilatory Response in Rodents.- Histochemical Demonstration of Carbonic Anhydrase in the Larynx.- Effects of Intralaryngeal CO2 And H+ on Laryngeal Receptor Activity in the Perfused Larynx in Cats.- The Effects of Airway CO2 on Laryngeal Pressure, ‘Drive’ and Cold Receptors in Spontaneously Breathing Cats.- Laryngeal Receptors are Sensitive to Expiratory Concentrations of CO2.- The Effects of Airway CO2 and Cooling on Ventilation and Upper Airway Resistance in Anaesthetized Rats.- The Effects of Laryngeal CO2 and Cooling on Ventilation and Laryngeal Resistance in the Anaesthetized Rat.