Applied Immunohistochemistry in the Evaluation of Skin Neoplasms

ISBN-13: 9783319305882 / Angielski / Twarda / 2016 / 385 str.

Jose Plaza; Victor G. Prieto

Opis

This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains. Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists.

Spis treści

Contents

List of Contributors

Part I: Immunohistology of Epithelial Tumors

1  Immunohistology and Molecular Studies of Epithelial Tumors

      Heather M. Froehlich and Jose A. Plaza

Part II: Adnexal Neoplasms

2  Immunohistology and Molecular Studies of Sweat Gland Tumors

      Ana M. Molina-Ruiz, Laura Fuertes, and Luis Requena

3  Immunohistology and Molecular Studies of Follicular Tumors

      Olayemi Sokumbi and Jose A. Plaza

4  Use of Immunohistochemical and Molecular Studies in the Evaluation of the Sebaceous Neoplasms

       Doina Ivan, Victor G. Prieto, and Phyu P. Aung

 

Part III: Immunohistology of Cutaneous Metastases and Its Simulators

5  Cutaneous Metastasis

      Danielle M. Wehle, Sadia Salim, and Martin A. Sangueza

 

Part IV: Immunohistology of Mesenchymal Neoplasms

6  Immunohistology and Molecular Studies of Fibrohistiocytic and Myofibroblastic Cutaneous Tumors

     Danny Ghazarian, Sebastien Labonte, Brendan Craig Dickson, and Ayman Al Habeeb

7  Immunohistology and Molecular Studies of Smooth Muscle and Neural Cutaneous Tumors

     Tammie Ferringer

8  New Insights in Vascular Lesions Development and Identification with Immunohistochemical Markers

      Omar P. Sangüeza and Julio A. Diaz-Perez

 

Part V: Immunohistology of Cutaneous Lymphoma

9  Immunohistology and Molecular Studies of Cutaneous B-cell Lymphomas

      Juan F. García

10  Immunohistology and Molecular Studies of Cutaneous T-cell Lymphomas and Mimics

    Carlos A. Torres-Cabala, Phyu P. Aung, Roberto N. Miranda, and Jonathan L. Curry

11  Immunohistology of Leukemia Cutis and Histiocytic Tumors

      Maria Teresa Fernández Figueras, Gustavo Tapia, José Luis Mate, Aurelio Ariza

 

Part VI: Immunohistology of Melanocytic Lesions

 

12  Immunohistology of Melanocytic Lesions

       Jonathan L. Curry, Michael T. Tetzlaff, Priyadharsini Nagarajan, and Carlos A. Torres-Cabala

 

Part VII: Molecular Studies of Melanocytic Lesions

 

13  Molecular Studies of Melanocytic Lesions

      Rami Al-Rohil, Priyadharsini Nagarajan, and Michael T. Tetzlaff

 

Part VIII: Immunohistology of Sentinel Lymph Node in Melanoma

 

14  Sentinel Lymph Node in Melanoma

       Victor G. Prieto

O autorze

Jose A. Plaza, MD

Miraca Life Science, Dermatopathology Division

Dallas, Texas, USA

 

Victor G. Prieto, MD, PhD

University of Texas, M. D. Anderson Cancer Center

Department of Pathology

Houston, Texas, USA

Blurb

This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. The book reviews in detail the sensitivity and specificity of commonly available antibodies and their pattern of immunostaining. Readers will learn when to order antibodies and how to interpret findings. In addition, prognostic markers are evaluated and emphasis placed on the pitfalls commonly encountered when evaluating these neoplasms. The informative text is complemented by a wealth of superb images. Helpful histograms and algorithms are included, and clear guidance is provided on the application and interpretation of less commonly used antibodies and immunostains.

With the emergence of many immunomarkers, immunohistochemistry has become a vital ancillary diagnostic tool in dermatopathology and an essential adjunct for the correct identification of skin neoplasms. Indeed, immunohistochemistry has replaced simple morphologic evaluation as the definitive diagnostic method for various tumor types. The complexity of some skin neoplasms makes it imperative that the role of immunohistochemistry in subtyping these conditions is clearly understood. Against this background, Applied Immunohistochemistry in the Evaluation of Skin Neoplasms will serve as an extremely valuable resource for practicing dermatopathologists and pathologists.