Apoptotic and Non-Apoptotic Cell Death

ISBN-13: 9783319239125 / Angielski / Twarda / 2017 / 183 str.

Shigekazu Nagata; Hiroyasu Nakano

Opis

Apoptosis is a prototype of regulated cell death and is executed by the sequential activation of caspases, and plays a crucial role in the process for development and tissue homeostasis of multicellular organisms. In the process of apoptosis, dead cells produce a find me signal to recruit phagocytes, and present an eat me signal. The prompt clearance of dead cells by phagocytes prevents the release of noxious materials from dying cells that may activate the immune system to develop autoimmune diseases. In addition, apoptotic cells release various factors that are involved in inflammation, proliferation, immune tolerance, and tissue repair in a context dependent manner. In addition to apoptosis, current studies revealed various types of non-apoptotic forms of cell death including regulated necrosis, pyroptosis, entosis, and ferroptosis etc. Among them, the regulated necrosis, also called necroptosis, plays a crucial role in ischemic reperfusion injury, drug-induced pancreatitis, and elimination of virus infection. Whereas, pyroptosis is the cell death induced by bacteria or viral infection, and entosis is the killing through the cell-in cell structure. The molecular mechanisms of these cell death processes are currently extensively studied. In this text book, current advances of cell death research and its future direction will be introduced and discussed."

Spis treści

Prix fixe: Efferocytosis as a four-course meal.- Emerging roles for RIPKs in pathogen-induced cell death and host immunity.- Epithelial cell death and inflammation in skin.- IAPs and cell death.- Cellular FLICE-inhibitory protein regulates tissue homeostasis.- Lipid peroxidation dependent cell death regulated by GPx4 and ferroptosis.- Immune regulation by dead cell clearance.

O autorze

Shigekazu Nagata is a professor of Graduate School of Medicine, Kyoto University, Japan. Hiroyasu Nakano is a professor of Graduate School of Medicine, Toho University, Japan.

Blurb

This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.