Apoptosis: Mechanisms and Role in Disease

ISBN-13: 9783662216255 / Angielski / Miękka / 2013 / 255 str.

Sharad Kumar

Opis

Apoptosis is currently one of the fastest moving fields in biology with spec- tacular progress made over the past few years in delineating the molecular mechanisms which underlie this process. It is nowindisputable thatapoptosis plays an essential role in normal cell physiology and that aberrant apoptosis can manifest itself in a variety of human disorders. Published in two parts (Volumes 23 and 24 of the series entitled Results and Problems in Cell Dif- ferentiation), this is an attempt to bring together many different aspects of apoptosis. Given that this is such a vast and rapidly expanding field, it is almost impossible to cover everything that is now known about apoptosis in two short books, but I hope these volumes prove to be a guidepost, provid- ing basic essential information on the biology and molecular mechanisms of apoptosis and its implications in some human diseases. Asasignificantamount of newinformation on apoptosis isemerging every week, it isunrealistic to expect that by the time these two books are published, allthe articles willdeliver up-to-date information.Nevertheless, Ibelieve that the fundamentals of the apoptotic phenomenon are now firmly in place and are discussed at length in various chapters. Readers may find a small degree of overlap between some chapters. This was unavoidable since closelyrelated areas of apoptosis research have been covered by more than one author

Spis treści

Caspases in Cell Death.- Proteolytic Targets in Cell Death.- The Point of No Return: Mitochondria, Caspases, and the Commitment to Cell Death.- Serpins and Regulation of Cell Death.- The IAP Family of Apoptotic Regulators.- Apoptosis Versus Necrosis: The Shape of Neuronal Cell Death.- Prevention of Neuronal Cell Death by Bcl-2.- CD95 (APO-1/Fas) in Hematopoietic Diseases.- The Cornified Envelope: A Model of Cell Death in the Skin.- Radiation-Induced Cell Death and its Implications in Human Disease.- T Cell Apoptosis in HIV Infection: Mechanism and Relevance for AIDS Pathogenesis.

Blurb

The past few years have seen rapid progress in apoptosis research. This volume deals with many of the recent advances made in uncovering the molecular and cellular basis of apoptosis and elaborates on how this accumulating knowledge is helping us to understand the significance of apoptosis in pathogenesis of diseases arising from inappropriate cell death. Further, mechanistic aspects of cell death and role of apoptosis in disease is covered.
The articles published in this volume are written by leading experts in the field and should be a vital resource for researchers in biomedicine and cancer research.