Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 2

ISBN-13: 9781588298829 / Angielski / Twarda / 2007 / 402 str.

Rakesh Srivastava

Opis

(for both volumes)
Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 & 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.
Volume 1 is divided into two sections: "Malignant Transformation and Metastasis" and "Molecular Basis of Disease Therapy." Volume 2 follows a similar structure and is divided into sections entitled "Kinases and Phosphate" and "Molecular Basis of Cell Death." All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically
examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.

Recenzje

"...an up-to-date synthesis of information regarding mechanisms of cell cycle control and apoptosis...filled with useful information and key references for readers familiar with this field." -Doody's Book Review, Weighted Numerical Score 77 - 3 stars

"...provides a snapshot of current research as well as a vision of research opportunities and cancer therapies yet to come." -Doody's Book Review, Weighted Numerical Score 77 - 3 stars

Spis treści

Section I. Kinases and Phosphatases Significance of Protein Kinase A in Cancer Maria V. Nesterova and Y. S. Cho-Chung Protein Kinase C and Cancer Mary E. Reyland The Role of PI3K-Akt Signal Transduction in Virus Infection Samantha Cooray Cyclin-Dependent Kinase 5: A Target for Neuroprotection? Frank Gillardon Critical Roles of the Raf/MEK/ERK Pathway in Apoptosis and Drug Resistance James A. McCubrey, Fred E. Bertrand, Linda S. Steelman, Fumin Chang, David M. Terrian, and Richard A. Franklin MAP Kinases Signaling in Human Diseases Philippe Roux and J.Blenis Serine/Threonine Protein Phosphates in Apoptosis Gro Gausdal, Camilla Krakstad, Lars Herfindal, and Stein Ove Doskeland Urokinase/Urokinase Receptor-Mediated Signaling in Cancer Sreerama Shetty, and Steven Idell Section II. Molecular Basis of Cell Death Signaling Pathways That Protect the Heart Against Apoptosis Induced by Ischemia and Reperfusion Zheqing Cai and Gregg L. Semenza Cyclooxygenase-2 Gene Expression: Transcriptional and Posttranscriptional Controls in Intestinal Tumorigenesis Shrikant Anant and Sripathi M. Sureban Death Receptors: Mechanisms, Biology and Therapeutic Potential Sharmila Shankar and Rakesh Srivastava DNA Damage-Dependent Apoptosis Tomasz Skorski The Role of Proteasome in Apoptosis Peter Low Apoptosis Induction in T Lymphocytes by HIV Maria Saveria Gilardini Montani Inhibitors of Apoptosis Proteins and Caspases Jai Yu, John Silke and Paul G. Ekert Intracellular Pathways Involved in DNA-Damage and Repair to Neuronal Apoptosis Maurizio Memo The Biology of Caspases Tasman James Daish and Sharad Kumar