Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 1

ISBN-13: 9781617377136 / Angielski / Miękka / 2010 / 384 str.

Rakesh Srivastava

Opis

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology. Volume 1 is divided into two sections: Malignant Transformation and Metastasis and Molecular Basis of Disease Therapy. Volume 2 follows a similar structure and is divided into sections entitled Kinases and Phosphate and Molecular Basis of Cell Death. All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases."

Spis treści

Section I. Malignant Transformation and Metastasis BCR-ABL and Cancer María Pérez-Caro and Isidro Sanchez-Garcia Angiogenesis and Cancer Yohei Maeshima Metastasis: The Evasion of Apoptosis Christine E. Horak, Jolie L. Bronder, Amina Bouadis, and Patricia S. Steeg Carcinogenesis: Balance Between Apoptosis and Survival Pathways Dean G. Tang and Jim Kehrer Aberrations of DNA Damage Checkpoints in Cancer Marikki Laiho c-Myc, Apoptosis and Disordered Tissue Growth Michael Khan and Stella Pelengaris Role of Lysophospholipids in Cell Growth and Survival Ianjun Fang and Sarah Spiegel Alternative Use of Signaling by the GBP Cytokine in Cell Growth and Cancer Control: From Surveillance to Therapy Livio Mallucci and Valerie Wells Control Nodes Linking the Regulatory Networks of the Cell Cycle and Apoptosis Baltazar D. Aguda, Wee Kheng Yio, and Felicia Ng Section II. Molecular Basis of Disease Therapy Regulation of NF B Function: Target for Drug Development Daniel Sliva and Rakesh Srivastava 5-Fluorouracil: Molecular Mechanisms of Cell Death D. B. Longley and P. G. Johnston Apoptosis-Inducing Cellular Vehicles for Cancer Gene Therapy: Endothelial and Neural Progenitors Gergely Jarmy, Jiwu Wei, Klaus-Michael Debatin, and Christian Beltinger Apoptosis and Cancer Therapy Maurice Reimann, and Clemens Schmitt Coupling Apoptosis and Cell Division Control in Cancer: The Survivin Paradigm Dario C. Altieri Clinical Significance of Histone Deacetylase Inhibitors in Cancer Sharmila Shankar and Rakesh K. Srivastava