Antisense Therapeutics

ISBN-13: 9781617374210 / Angielski / Miękka / 2010 / 344 str.

M. Ian Phillips

Opis

A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.

Recenzje

From Reviews of the First Edition...

"...strongly recommended both to scientists already engaged in antisense research and to newcomers alike." -Trends in Biotechnology

"...enables an appreciation of the exciting possibilities this field offers for the development of new uniquely selective therapeutic agents via precisely designed inhibitors of the expression of disease associated genes." -Journal of Medicinal Chemistry

Reviews from the Second Edition...

"This book does an excellent job of showing the reader that antisense oligonucletoids could be valuable therapeutic drugs in the future." - Doody's Health Sciences Book

Spis treści

Part I. Introduction Antisense Therapeutics: A Promise Waiting to be Fulfilled M. Ian Phillips Antisense Inhibition: Oligonucleotides, Ribozymes, and siRNAs Y. Clare Zhang, Meghan M. Taylor, Willis K. Samson, and M. Ian Phillips Part II. Cardiovascular Local Application of Antisense for Prevention of Restenosis Patrick L. Iversen, Nicholas Kipshidze, Jeffrey W. Moses, and Martin B. Leon Antisense Therapeutics for Hypertension: Targeting the Renin-Angiotensin System M. Ian Phillips and Birgitta Kimura Antisense Strategies for the Treatment of Heart Failure Sian E. Harding, Federica del Monte, and Roger J. Hajjar Part III. Cancer Clinical Studies of Antisense Oligonucleotides for Cancer Therapy Rosanne M. Orr and F. Andrew Dorr Antisense Therapy in Clinical Oncology: Preclinical and Clinical Experiences Ingo Tamm Radionuclide-Peptide Nucleic Acid Diagnosis and Treatment of Pancreatic Cancer Eric Wickstrom, Xiaobing Tian, Nariman V. Amirkhanov, Atis Chakrabarti, Mohan R. Aruva, Ponugoti S. Rao, Wenyi Qin, Weizhu Zhu, Edward R. Sauter, and Mathew L. Thakur Suppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors Kazunori Aoki, Shumpei Ohnami, and Teruhiko Yoshida Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategies Manuel Rieber and Mary Strasberg-Rieber Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistance Tadao Funato Part IV. Blood-Brain Barrier Transport of Antisense Across the Blood-Brain Barrier Laura B. Jaeger and William A. Banks Part V. Dermal Transdermal Delivery of Antisense Oligonucletoides Rhonda M. Brand and Patrick L. Iversen Part VI. Drugs Antisense Strategies for Redirection of Drug Metabolism: Using Paclitaxel as a Model Vikram Arora Part VII. Gastrointestinal Antisense Oligonucleotide Treatment of Inflammatory Bowel Diseases Bruce R. Yacyshyn Part VIII. Hepatitis Optimizing Electroporation Conditions for the Intracellular Delivery of Morpholino Antisense Oligonucleotides Directed Against the Hepatitis C Virus Internal Ribosome Entry Site Ronald Jubin Index

Blurb

Announcement of the complete sequencing of the human genome in April 2003 demonstrated the presence of thousands of targets for antisense oligonucleotides and opened the way to hundreds of preclinical animal studies and some 20 ongoing clinical trials. In this second edition of Antisense Therapeutics, a team of leading researchers and clinical scientists demonstrate the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.
Highly practical and disease oriented, Antisense Therapeutics, Second Edition offers not only a primer for a new generation of drug discovery researchers, but also an illuminating exploration of the potential in exploiting RNA inhibition for novel human therapeutics.