Antimicrobial Pharmacodynamics in Theory and Clinical Practice

ISBN-13: 9780824729257 / Angielski / Twarda / 2007 / 536 str.

Charles H. Nightingale; Paul G. Ambrose; George L. Drusano

Opis

Analyzing the wide array of scientific and medical literature currently available, this guide contains discussions that lead the reader through test tube research and animal and human studies to clinical treatment settings merges developments in medical microbiology, clinical infectious disease, and pharmacokinetics helps readers improve their understanding of the pharmacodynamics and appropriate use of antibiotics Taking readers from the research laboratory to the bedside, this Second Edition compiles essential information on the pharmacodynamics of all major classes of the antimicrobial armamentarium including penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and emerging agents currently in development. Referencing the most current literature in the field, this guide uses an abundance of examples to depict methods to apply pharmacodynamic concepts to everyday clinical practicles.

Spis treści

Introduction. Pharmacodynamics of Antimicrobials: General Concepts and Applications Impact of Pharmacodynamics on Breakpoint Selection for Susceptibility Testing. Non-Clinical Models of Infection. In Vitro Antibiotic Pharmacokinetic Models. Animal Models of Infection for the Study of Antibiotic Pharmacodynamics. The Predictive Value of Laboratory Tests for Efficacy of Antibiotic Combination Therapy. Antibacterial Agents. Beta-Lactam Antibiotics. Aminoglycoside Antibiotics. Quinolones. Glycopeptides. Macrolide, Azalide and Ketolides. Metronidazole, and Clindamycin. Streptogramins, Oxazolididones. Tetracyclines. Antiviral Agents. Nucleoside Reverse Transcriptase Inhibitors. Protease Inhibitors. Hepatitis B and C. Antifungal Agents. Amphotericin. Azoles. Gulcan Synthase Inhibitors. Antimalarial Agents. Anti-Malarials. Pharmacodynamics in Drug Development. Human Pharmacodynamics of Anti-Infectives: Determination from Clinical Trial Data. Pharmacodynamics in Global Bridging Studies. Toxicodynamics. Pharmacodynamics and Resistance. Antibacterial Resistance. Application of PK-PD to Clinical and Formulary Decisions. Basic Pharmacoeconomics. Utilizing Pharmacodynamics and Pharmacoeconomics in Clinical and Formulary Decision Making.

O autorze

Nightingale, Charles H.; Ambrose, Paul G.; Drusano, George L.; Murakawa, Takeo