'The book contains a wealth of information both for everyday practice and for more theoretical aspect. Interactions between AED ... covered in great detail. ... Why is this book so important? The authors explain it in their foreword. As a substantial proportion of patients with epilepsy will not become seizure free with one drug, combination therapy is necessary and therefore often used.' Official Journal of the European Paediatric Neurology Society
1. Combination therapy of diseases: general concepts Emma Lam and Philip A. Routledge; 2. Combination therapy with antiepileptic drugs: potential advantages and problems Richard H. Mattson; 3. Pharmacogenetic aspects M. C. Walker, M. R. Johnson and Philip N. Patsalos; 4. Pharmacokinetic principles and mechanisms of drug interactions Philip N. Patsalos; 5. Predictability of metabolic antiepileptic drug interactions Edoardo Spina, Emilio Perucca and Rene Levy; 6. Influence of food and drugs on the bioavailability of antiepileptic drugs C. A. Fontes Ribeiro; 7. Interactions between antiepileptic drugs Bernhard Rambeck and Theodor W. May; 8. Interactions between antiepileptic and non-antiepileptic drugs Jerzy Majkowski and Philip N. Patsalos; 9. Pharmacodynamic principles and mechanisms of drug interactions Blaise F. D. Bourgeois; 10. Methods for assessing pharmacodynamic interactions Blaise F. D. Bourgeois; 11. Experimental studies of pharmacodynamic interactions Stanislaw J. Czuczwar; 12. Clinical studies of pharmacodynamic interactions John R. Pollard and Jacqueline French; 13. Clinical studies of pharmacodynamic interactions between antiepileptic agents and other drugs Gaetano Zaccara, Andrea Messori and Massimo Cincotta; 14. Antiepileptic drug interactions in children Olivier Dulac, Elizabeth Rey and Catherine Chiron; 15. Antiepileptic drug interactions in the elderly James C. Cloyd and Jeannine M. Conway; 16. Antiepileptic drug interactions in pregnancy Mark S. Yerby; 17. Antiepileptic drug interactions in handicapped and mentally retarded patients Matti Sillanpaa; 18. Antiepileptic drugs and sex steroids Richard H. Mattson; 19. Antiepileptic drug interactions in patients requiring psychiatric drug treatment Michael R. Trimble and Marco Mula; 20. Antiepileptic drugs in non-epileptic health conditions - possible interactions Jerzy Majkowski; 21. Drug monitoring in combination therapy W. Froscher; 22. Cognitive side-effects due to antiepileptic drug combinations and interactions Albert P. Aldenkamp, Mark de Krom, I. Kotsopoulos and Jan Vermeulen; 23. Selection of drug combinations in clinical practice - current and future perspectives Jerzy Majkowski; 24. Future research - an experimental perspective R. A. Voskuyl, D. M. Jonker and R. H. Lopes da Silva; 25. Future research - a clinical perspective C. A. Fontes Ribeiro.