Antiepileptic Drug Discovery: Novel Approaches

ISBN-13: 9781493981748 / Angielski / Miękka / 2018 / 386 str.

Alan Talevi; Luisa Rocha

Spis treści

Part I: Novel Approaches for the Treatment of Epilepsy

 

1. Inflammatory Cytokines as Targets for Epilepsy Drug Therapy

            María-Leonor López-Meraz, Jesús-Servando Medel-Matus, and Jerome Niquet

 

2. The Use of Anti-Inflammatory Drugs in Epilepsy

            María Guadalupe Valle-Dorado, Laura Elena Córdova-Dávalos, Daniel Pérez-Pérez, Rosalinda Guevara-Guzmán, and Luisa Rocha

 

3. Carbonic Anhydrase and Epilepsy

            Luciana Gavernet

 

4. Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs

            Luz Adriana Pichardo-Macías, Itzel Jatziri Contreras-García, Sergio R. Zamudio, Edgar Mixcoha, and Julieta G. Mendoza-Torreblanca

 

5. Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?

            Cecilia Zavala-Tecuapetla and Luisa Rocha

 

6. Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy

            Manola Cuellar-Herrera, César E. Santana-Gómez, Francia Carmona-Cruz, Daruni Vázquez-Barrón, Francisco Velasco, and Ana L. Velasco

 

7. Neurosteroid Regulation of Seizures: Role of GABA_A Receptor Plasticity

            Suchitra Joshi and Jaideep Kapur

 

8. Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy

            Amalia Marelli, Liliana Czornyj, Luisa Rocha, and Alberto Lazarowski

 

9. Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery

            Karla G. Carvajal Aguilera and Bryan V. Phillips Farfán

 

10. Gene Therapy in Epilepsy

            Miguel A. López-García, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, and Sandra Orozco-Suarez

 

Part II: Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing the Multi-Drug Resistance Issue Epilepsy

 

11. Human Brain Tissue as a Model for the Study of Epilepsy

            Leonardo Lara-Valderrábano, Ivette Bañuelos-Cabrera, Víctor Navarrete-Modesto, and Luisa Rocha

 

12. The Blood-Brain Barrier and the Design of New Antiepileptic Drugs

            Gabriela Rogel-Salazar and Hiram Luna-Munguia

 

13. Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates

            Alan Talevi and Luis E. Bruno-Blanch

 

14. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations

            Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi, and Luis E. Bruno-Blanch

 

15. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations

            Pablo Palestro and Luciana Gavernet

 

16. Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies

            María E. Ruiz and Guillermo R. Castro

 

Part III: Potential Contributions of Network Pharmacology and Drug Repurposing in Antiepileptic Drug Discovery

 

17. Side Effects of Antiepileptic Drugs

            Hana Kubova

 

18. Network Pharmacology and Epilepsy

            Alan Talevi

 

19. The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development

            Alan Talevi

Blurb

This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. 

Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.