Anticarcinogenic activity of Clerodendrum serratum in albino mice

ISBN-13: 9783659640858 / Angielski / Miękka / 2014 / 152 str.

Chinchali, Jayaraj

Opis

Skin, a major environmental interface for the body, is accidentally or occupationally exposed to a number of chemical mutagens and carcinogens. Skin cancer accounts for 30% of all diagnosed cancers in the world. The evaluation of anticarcinogenic activity of Clerodendrum serratum leaf extract on DMBA induced skin carcinogenesis in swiss albino mice revealed that there was decrease in the body and organs weight, affected biochemical contents, dehydrogenases and phosphatases activities and oxidative stress parameters of liver, kidney and testes of mice. Amelioration in the above mentioned parameters was observed on treatment with methanolic leaf extract of Clerodendrum serratum, indicating its anticarcinogenic potential. The inferences drawn from the study revealed that the methanolic leaf extract of Clerodendrum serratum recovered the biochemical contents, dehydrogenases and phosphatases activity and oxidative stress parameters of liver, kidney and testes of mice. The presence of major chemical components such as phenolics, steroids, diterpenes and triterpenes, flavonoids and volatile oils attributed its chemopreventive potential as an antioxidant and antiproliferative agent........

O autorze

Dr. Jayaraj F. Chinchali presently working as Assistant Coordinator, Department of Zoology, Davangere University, India completed his Ph.D in Biotechnology in 2014 and M.Phil in Biotechnology in 2011 from Karnatak University, Dharwad, India. Thrust areas of research are Preclinical studies on mouse, Medical Biotechnology and Molecular Cell Biology.