Antibodies in Viral Infection

ISBN-13: 9783642074868 / Angielski / Miękka / 2010 / 309 str.

Dennis R. Burton

Opis

Antibodies are central to vaccines and it is becoming increasingly apparent that understanding how antibodies combat viruses could be crucial in a new era of vaccine development. This book describes the state of the art in explaining the anti-viral activity of antibodies at the molecular level, with chapters from many of the leaders in the field.

Spis treści

Antibody interactions with rhinovirus lessons for mechanisms of neutralization and the role of immunity in viral evolution.- Structural studies on antibody with viruses.- Shape and electrostatic complementarity at viral antigen-antibody complexes.- Structural studies on viral escape from antibody neutralization.- Affinity, complementarity, cooperativity, and specificity in antibody recognition.- Mechanisms of virus neutralization by antibody.- Neutralization of viruses is achieved by antibody coating of the virion surface.- Anti-mediated enhancement of viral disease.- The role of antibody response in influenza virus infection.- Role of antibodies in controlling alphavirus infection of neurons.- Role of mucosal antibodies in viral infections.- The role of the complement system in virus infection.- Intrabodies as anti-viral agents.- T-bodies as anti-viral agents.- Subject index.

Blurb

The huge mortality and morbidity of the AIDS pandemic and outbreaks due to emerging pathogens such as Ebola virus and hantavirus underline the vulnerability of mankind to viral infection. By far the most successful anti-viral strategy to date has been vaccination but the development of vaccines against viruses such as HIV, the cause of AIDS, is proving difficult. Antibodies are central to vaccines and it is becoming increasingly apparent that understanding how antibodies combat viruses could be crucial in a new era of vaccine development. This book describes the state of the art in explaining the anti-viral activity of antibodies at the molecular level with chapters from many of the leaders in the field. It will appeal to anyone interested in the fight against viruses.