Antibiotic Pharmacodynamics

ISBN-13: 9781493933211 / Angielski / Twarda / 2016 / 666 str.

John C. Rotschafer; David R. Andes; Keith A. Rodvold

Opis

This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.

Spis treści

1. General Concepts of Pharmacodynamics for Anti-Infective Agents

            Johan W. Mouton

 

2. In Vitro Pharmacodynamic Models to Evaluate Anti-Infective Pharmacodynamics

            Warren Rose

 

3. Animal Models to Evaluate Anti-Infective Pharmacodynamics

            Alexander J. Lepak and David R. Andes

 

4. Pharmacodynamic Issues in Antibiotic Combinations

            Zackery P. Bulman, Ryan C. Dillon, Sarith M. Saju, Neang S. Ly, Gauri G. Rao, Phillip J. Bergen, Cornelia B. Landersdorfer, Alan Forrest, Juergen B. Bulitta, and Brian T. Tsuji

 

5. Methodologies for Protein Binding Determination in Anti-Infective Agents

   

         Jatinder Kaur Mukker, Ravi Shankar Prasad Singh, and Hartmut Derendorf

 

6. Evaluation of Exposure-Response Relationships Using Clinical Data: Basic Concepts and Applications<

            Sujata M. Bhavnani, Christopher M. Rubino, and Paul G. Ambrose

 

7. Toxicokinetics and Toxicodynamics of Anti-Infective Agents

            David E. Nix

 

Part II: Pharmacodynamics of Antibacterial Agents

 

8. Pharmacodynamics of Fluoroquinolones

            Ramy Elshaboury, Thomas Dilworth, and John Rotschafer

 

9. Aminoglycoside Pharmacodynamics

        

    Dana R. Bowers, Amy N. Schilling, and Vincent H. Tam

 

10. Polymyxin Phar

macokinetics and Pharmacodynamics

            Soon-Ee Cheah, Jian Li, Phillip J. Bergen, and Roger L. Nation

 

11. Vancomycin Pharmacodynamics: Optimal vs. Controversial

            Ben M. Lomaestro

 

12. Pharmacodynamics of Lipoglycopeptides

Eric Wenzler, Siyun Liao, and Keith A. Rodvold

 

<13. Pharmacodynamics of Daptomycin

            Eric Wenzler, Siyun Liao, and Keith A. Rodvold

 

14. Pharmacodynamics of Macrolides, Azalides, and Ketolides

            Wonhee So and David P. Nicolau

 

Part III: Pharmacodynamics of Non-Antibacterial Agents

           

15. Antifungal Pharmacokinetics and

Pharmacodynamics

            William Hope and David R. Andes

 

16. Pharmacokinetics and Pharmacodynamics of the Tuberculosis Drugs

            Aline B. Barth, Eric F. Egelund, and Charles A. Peloquin

 

17. Pharmacodynamics of Antimalarial Agents

            Rahul P. Bakshi and Theresa A. Shapiro

 

18. Pharmacodynamics of Antiviral Agents

            Renee-Claude Mercier, Bernadette Jakeman, and Larry Pineda

 

19. Pharmacodynamics of Antiretroviral Agents

            K

ajal B. Larson and Edward P. Acosta

 

Part IV: Pharmacodynamic Considerations and Special Populations

 

20. Implementing a Continuous or Prolonged Infusion Be

ta-Lactam Program in the Hospital Setting

            Shawn H. MacVane, Nathaniel J. Rhodes, Marc H. Scheetz, and Joseph L. Kuti

 

21. Pharmacodynamic Considerations in Critically Ill Patients

            Mahipal G. Sinnollareddy and Jason A. Roberts

 

22. Pharmacodynamic Considerations and Special Populations: Pediatrics

            Jennifer Le and John S. Bradley

 

23. Pharmacodynamics and Obesity

            Manjunath P. Pai

 

24. Drug Development Process and Regulatory Science

            Evelyn J. Ellis-Grosse and Jogarao Gobburu

 

25. Antibiotic Stewardship an

d Applications of Pharmacodynamics

            Elizabeth D. Hermsen and Lynne Fehrenbacher