Antibacterial Drug Discovery to Combat MDR: Natural Compounds, Nanotechnology and Novel Synthetic Sources

ISBN-13: 9789811398735 / Angielski / Miękka / 2020 / 680 str.

Iqbal Ahmad; Shamim Ahmad; Kendra P. Rumbaugh

Spis treści

Section A: Problems associated with current antimicrobial therapy

1. Antibacterial drug discovery : perspective insights

2. Emergence and spread of multidrug resistance in ocular pathogens

3. Problematic groups of MDR bacteria and their resistance mechanisms

4. Biofilms in relation to enhanced drug resistance and persistence infection: challenges in chemotherapy

5. Environmental MDR a potential threat to human health and antimicrobial therapy

6. Impediments to discovery of new antimicrobials with new modes of action

7. Developing in vivo infection models with MDR pathogens for evaluating compound efficacy

Section B: New antibiotic drug discovery approaches and progress

8. Classical to improved microbial screening approaches for antibacterial drug discovery

9. Endophytes: a hidden treasure of novel antimicrobial metabolites

10. New molecular drug targets: potential for developing novel antibacterials against MDR bacteria

11. Bio-synthetic gene clusters associated with marine sponge and with bacterial dwelling in marine sponges

12. Insilico molecular modelling for drug screening

bioinformatics and chemoinformatics: key technologies in the drug discovery process

13. Computational Approaches in relation to antibacterial drug discovery

14. Efflux pump inhibitors and their role in reversal of drug resistance

15. Medicinal plants as reservoir of new structure for anti-infective compounds

16. Antibacterial essential oils: Potential application in bacterial disease management.

17. Metagenomic approach to explore soil resistome.

18. Marinemicrobes as promising source of new leads as antibacterials: Current progress and prospects

Section C:Alternative antibiotic resistance treatment strategy

19. Role of pre and probiotics in protection from pathogenic bacteria

20. Enhancing antibiotic efficacy through synergistic approach

21. Reviving old antibiotics

22. Targeted Delivery of antibiotics using polymeric particles to combat TB resistance

23. Bacteriophages in pathogenic bacterial control: prospects and limitation.

24. Inhibition of Quorum sensing; prospects in disease control

25. Pathogenic Biofilm eradication strategies in combating bacterial infection

Section D:Nanomaterials as antibacterial drug: potentials and prospects

26. Nanomedicine /Nanoemulsion in increasing drug availability

27. Nanoparticle as new emerging antibacterials: potential and limitation

28. Antibiofilm and antivirulence action of nanopartciles

29. Nanoparticle-based drug delivery systems: promising approaches against bacterial infections

30. Green synthesis of metal nanoparticles: characterization and their antibacterial efficacy

31. Protein and Peptide Nanoparticles for antibacterial Drug Delivery

O autorze

Professor Iqbal Ahmad

Iqbal Ahmad is a Full Professor and former Chair of the Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh, India.  He is also the Coordinator, Faculty of Agricultural Sciences, AMU for the BSc (Hons) Agriculture course.  He has extensive teaching and research experience in applied & interdisciplinary microbiology and medicinal plant-derived natural products. His present research interest is in the field of AMR in pathogenic bacteria of environmental and clinical origin and conducting research on interference of quorum sensing-linked virulence factors and biofilms by natural products including medicinal plants as a possible alternative strategy to combat MDR. Dr. Ahmad has published more than 150 original research papers, 10 edited books, and 50 book chapters. In addition, he serves as an active reviewer/member of the editorial board for many prominent research journals. 

Prof (Dr.) Kendra P. Rumbaugh

Kendra Rumbaugh is a Professor at the Department of Surgery, with joint appointments at the Departments of Immunology and Molecular Microbiology and Cell Biology and Biochemistry at Texas Tech University Health Sciences Center in Lubbock, Texas. Dr. Rumbaugh’s research focuses on understanding and treating wound infections, and she is especially interested in how biofilms, polymicrobial interactions and quorum sensing contribute to bacterial pathogenesis. She has edited books on quorum sensing (Springer) and antibiofilm agents (Springer), and serves on many international science advisory boards, program committees and the editorial boards of many high ranked journals.

 

Prof (Dr.) Shamim Ahmad

Shamim Ahmad is a senior Professor of Ocular Microbiology at the Institute of Ophthalmology, JN Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, India. He has also served as faculty on deputation from AMU Aligarh at the Department of Clinical Microbiology, Al-Arab Medical University, Libya and at the Department of Medical Microbiology, College of Medicine, Faculty of Medicine, King Khalid University, Saudi Arabia. Prof. Ahmad has been a recipient of at least 6 International Fellowships including DAAD (Germany), JSPS (Japan), ROYAL SOC. London (UK), TUBA (Turkey) and SAIA (Slovak Republic) as a Visiting Professor, mostly sponsored by the Govt. of India. Having worked at seven laboratories around the world, his research work mainly involves Multi Resistant Eye Pathogens including Super Bugs, MRSAs and their alternative treatment with newer antibacterial and innovative natural products. Prof. Ahmad serves on the editorial boards of many prominent research journals.

Blurb

This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.