Antibacterial Activity of Selected Substituted Benzaldoximes

ISBN-13: 9786200093639 / Angielski / Miękka / 2019 / 128 str.

David Ike

Opis

This book deals with the synthesis of some substituted benzaldoximes from their corresponding benzaldehydes by the reaction of the alcoholic solution of these benzaldehydes with hydroxylamine in the presence of sodium hydroxide (NaOH) using ethanol/water solution as solvent medium. Structural elucidation of the synthesized compounds was carried out by infrared spectroscopy (IR) and Gas chromatography-Mass spectroscopy (GC-MS) analysis and the predicted structures is in agreement with spectral data obtained. The study revealed that this synthetic route produces bezaldoximes of good yields (74- 79%). The synthesized compounds (5a-d) were subjected further to screening for their antimicrobial ability against two Gram-positive bacteria (Bacillus subtilis strain AIMST 2ME11 and Bacillus cereus strain CF7) and three Gramnegative bacteria (Pseudomonas acruginosa strain PG1 and Pseudomonas aeruginosa Strain 333K35 and Eschericha coli). Their zones of inhibition were measured and it was revealed that compound 5a has no antibacterial ability against all five bacteria isolates tested against.

O autorze

Ike, David
David Chukwuebuka Ike is a research fellow at the World Bank Africa Centre of Excellent,Center for Oil Field Chemical Research, University of Port Harcourt, where he is pursuing a PhD degree in Synthetic Organic Chemistry. He has a Master degree in Pharmaceutical/Medicinal Chemistry and a Bachelor's degree in Chemistry from the UPH, Nigeria.