Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments, Volume 2

ISBN-13: 9781493960521 / Angielski / Miękka / 2016 / 718 str.

Jun Chen; Xiao-Ming Xu; Zao C. Xu

Opis

This book examines animal models of global cerebral ischemia, focal cerebral ischemia and neonatal hypoxia-ischemia, as well as traumatic brain injury and spinal cord injury. Offers step-by-step procedures and expert guidance on use of specific assessments.

Recenzje

"This an atlas-text 'protocols' step by step explanation of animal cerebral ischemia, brain trauma, & spinal cord injury. ... I recommend this book for ischemia and trauma students and physiology students." (Joseph J. Grenier, Amazon.com, October, 2015)

Spis treści

1. Introduction (Parts I-III)

            R. Anne Stetler and Miguel A. Perez-Pinzon

 

Part I: Global Cerebral Ischemia (GCI)

 

2. Morphological Assessments of Global Cerebral Ischemia: Viable Cells

            Peiying Li

 

3. Morphological Assessments of Global Cerebral Ischemia: Degenerated Cells

            Peiying Li

 

4. Morphological Assessments of Global Cerebral Ischemia: Electron Microscopy

            Irina S. Balan, Tibor Kristian, Chunli Liu, Andrew J. Saladino, and Bingren Hu

 

5. Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: mRNA

            R. Anne Stetler and Yu Gan

 

6. Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: Protein

            Yu Gan and R. Anne Stetler

 

7. Neurobehavioral Assessments of Global Cerebral Ischemia

            Pinar Kendigelen, Dandan Sun, and Pelin Cengiz<

 

8. Assessment of Neurogenesis in the Dentate Gyrus after Global or Focal Ischemia

            Wei Liu and Jialing Liu

 

Part II: Focal Cerebral Ischemia (FCI)

 

9. Infarct Measurement in Focal Cerebral Ischemia: TTC Staining

            Feng Zhang and Jun Chen

 

10. Morphological Assessments of Focal Cerebral Ischemia: White Matter Injury

            Feng Zhang and Lyanne C. Schlichter

 

11. Blood Flow Reduction: Laser Doppler, ¹⁴C-IAP

            Feng Zhang, Steven H. Graham, and Jun Chen

 

12. Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: mRNA and MicroRNA

            Yu Gan and R. Anne Stetler

 

13. Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: Protein

            R. Anne Stetler and Yu Gan

 

14. Assessments of Inflammation After Focal Cerebral Ischemia

            Xiaoming Hu and Jun Chen

 

15. Neurobehavioral Assessments of Focal Cerebral Ischemia: Sensorimotor Deficit

            Yejie Shi and Dandan Sun

 

16. Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit

            Yejie Shi and Dandan Sun

 

17. Assessment of Neurogenesis in Models of Focal Cerebral Ischemia

            Feng-Yan Sun, Xiao Sun, Ji-Jiang Wang, Qiu-Wan Zhang, and Yong-Quan Wang

 

18. Assessment of Angiogenesis in Models of Focal Cerebral Ischemia

            Hong Shi, Yanqin Gao, and Weimin Liang

 

Part III: Neonatal Hypoxia-Ischemia (NHI)

 

19. Morphological Assessments of Neonatal Hypoxia-Ischemia: In Situ Cell Degeneration

            Changlian Zhu and Klas Blomgren

 

20. Morphological Assessments of Neonatal Hypoxia-Ischemia: White Matter Injury

            Dianer Yang and Chia-Yi Kuan

 

21. Biochemical and Molecular Biological Assessments of Neonatal Hypoxia-Ischemia: Cell Signaling

            Changlian Zhu and Klas Blomgren

 

22. Biochemical and Molecular Biological Assessments of Neonatal Hypoxia-Ischemia: Inflammation

            Xiaoming Hu and Jun Chen

 

23. Neurobehavioral Assessments of Neonatal Hypoxia-Ischemia

            Masanori Iwai and Jun Chen

 

24. Assessment of Neurogenesis and White Matter Regeneration

            Masanori Iwai, Hiroko Tajiri, Shiro Matsumoto, Hiroshi Mitsubuch, and Fumio Endo

 

Part IV: Traumatic Brain Injury (TBI)

 

25. Assessments for Traumatic Brain Injury:  An Introduction

            Kathryn E. Saatman

 

26. Morphological Assessments of Traumatic Brain Injury

            Daniel van Bregt, Theresa Currier Thomas, Rachel D. Rowe, and Jonathan Lifshitz

 

27. Assessment of Cerebral Vascular Dysfunction after Traumatic Brain Injury

            Douglas S. DeWitt and Donald S. Prough

 

28. Assessment of Membrane Permeability After Traumatic Brain Injury

            Michelle C. LaPlaca and Marcus Chris Lessing

 

29. Assessment of Neurogenesis by BrdU Labeling After Traumatic Brain Injury

            Jinhui Chen and Xiang Gao

 

30. Electrophysiological Approaches in Traumatic Brain Injury

            Thomas M. Reeves and Beverly S. Colley

 

31. Biochemical and Molecular Biological Assessments of Traumatic Brain Injury

            Coleen M. Atkins and Anthony Andrew Oliva, Jr.

 

32. Assessments of Oxidative Damage and Lipid Peroxidation after Traumatic Brain Injury and Spinal Cord Injury

            Jeffrey M. Bosken, Juan A. Wang, and Edward D. Hall

 

33. Neurobehavioral Assessments of Traumatic Brain Injury

            James W. Bales, Kristin Macfarlane, and C. Edward Dixon

 

34. Vestibular Assessments Following Traumatic Brain Injury

            James W. Bales, Kristin Macfarlane, and C. Edward Dixon

 

Part V: Spinal Cord Injury (SCI)

 

35. Introduction on Assessments for Spinal Cord Injury

            Theo Hagg

 

36. Morphological Assessments Following Spinal Cord Injury

            Chandler L. Walker and Xiao-Ming Xu

 

37. Assessment of Lesion and Tissue Sparing Volumes Following Spinal Cord Injury

            Lyn B. Jakeman

 

38. Retrograde Axonal Tract Tracing

            Lingxiao Deng, Xiaofei Wang, Chandler L. Walker, Yiwen Ruan, and Xiao-Ming Xu

 

39. Anterograde Axonal Tract Tracing

            Xiaofei Wang, Lingxiao Deng, and Xiao-Ming Xu

 

40. Assessments of Gliogenesis After Spinal Cord Injury

            Drew L. Sellers and Philip J. Horner

 

41. Assessing Microvessels After Spinal Cord Injury

            Theo Hagg, Richard L. Benton, Janelle M. Fassbender, and Scott R. Whittemore

 

42. Physiological Assessment of Spinal Cord Injury

            Lisa B.E. Shields, Yi Ping Zhang, and Christopher B. Shields

 

43. Electrophysiological Assessment of Spinal Cord Function on Rodents Using tcMMEP and SSEP

            Yi Ping Zhang, Lisa B.E. Shields, and Christopher B. Shields

 

44. Operant Conditioning of Spinal Cord Reflexes in Rats

            Xiang Yang Chen and Jonathan R. Wolpaw

 

45. Cellular and Molecular Biological Assessments of Inflammation and Autoimmunity After Spinal Cord Injury

            Yi Zhang, Daniel P. Ankeny, and Phillip G. Popovich

 

46. Neurobehavioral Assessments of Spinal Cord Injury

            Jed S. Shumsky and John D. Houlé

 

47. Basso, Beattie, and Bresnahan (BBB) Scale Locomotor Assessment Following Spinal Cord Injury and Its Utility as a Criterion for Other Assessments

            Darlene A. Burke and David S.K. Magnuson

 

48. High Speed Video Recording Used for the Analysis of Hand Shaping in Over Ground Walking, Cylinder Exploration, Skilled Reaching, and Rung Walking in Rats

            Ian Q. Whishaw and Lori-Ann Sacrey

 

49. Automated Gait Analysis Following Spinal Cord Injury

            Jason E. Beare, Johnny R. Morehouse, David S.K. Magnuson, and Scott R. Whittemore

 

50. Forelimb Functional Assessments of Rats and Mice After Cervical Spinal Cord Injury

            Stephen M. Onifer

 

51. Swimming as an Assessment of Hindlimb Function in Animals with Traumatic Spinal Cord Injury

            Edward H. Brown, Johnny R. Morehouse, and David S.K. Magnuson

 

52. Neuroimaging Assessment of Spinal Cord Injury in Rodents

            Mehmet Bilgen

Blurb

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.  Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system.  Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury.  Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.

 

Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.