Animal Models for the Study of Human Disease

ISBN-13: 9780124158948 / Angielski / Twarda / 2013 / 1089 str.

P Michael Conn

Opis

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse.

• Organized by disease orientation for ease of searchability
• Provides information on locating resources, animal alternatives and animal ethics
• Covers a broad range of animal models used in research for human disease

Recenzje

"...addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine."-- Anticancer Research, February 2015

".a very detailed textbook for researchers and laboratory animal veterinarians interested in getting an understanding of some of the animal models of human diseases. The authors have done a good job of reviewing the numerous animal models in various physiological systems."-- Laboratory Animal Practitioner, June 2014

"Conn presents this compendium on animal models in biomedical research, beginning with a section on ethical justifications, resources, and methodology to optimize the scientific value obtained from animal experiments. After this discussion, the volume is organized by disease group.The book aims to present successful animal models with the greatest homology to human systems."-- ProtoView.com, February 2014

"This comprehensive textbook identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease.Organized by disease orientation for ease of searchability.Provides information on locating resources, animal alternatives and animal ethics."-- Anticancer Research, 34, 2014

".overall, the content (figures, tables and descriptions of the animal models and their significance) is excellent and should be considered a useful resource.Any laboratory animal research program, particularly those with an interest in working with multiple species of animal models, would benefit from having this book in the library."-- Lab Animal, February 2014

Spis treści

Preface

Section A. ETHICS, RESOURCES AND APPROACHES

Section B. VISION

Section C. CARDIAC AND CARDIOVASCULAR

Section D. OBESITY, METABOLIC AND LIVER

Section E. BONE AND SKIN

Section F. URINARY TRACT, KIDNEY AND BOWEL

Section G. THE BRAIN, STROKE, AND NEUROMUSCULAR

Section H. BEHAVIOR

Section I. GENETICS

Section J. EARLY LIFE

Section K. VIRAL DISEASE

Section L. CANCER

Section M. SCLEROSIS

O autorze

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public's awareness of diabetes. Conn's students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.