Animal Models for Stem Cell Therapy

ISBN-13: 9781493914524 / Angielski / Twarda / 2014 / 392 str.

Bruno Christ; Jana Oerlecke; Peggy Stock

Opis

In Animal Models for Stem Cell Therapy: Methods and Protocols, expert researchers in the field detail disease models of hepatic, cardiovascular, neurological diseases, connective and contractile tissue. Chapters focus on a wide range of diseases and application of different kinds of stem cells and reprogrammed tissue cells (iPS). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Animal Models for Stem Cell Therapy: Methods and Protocols, covers interest of basic scientists and clinicians to assess the biological as well as the therapeutic potential of stem cell therapy.

Spis treści

PART I  INTRODUCTION

 1          Stem Cells--Are We Ready for Therapy?

            Insa Schröder

2          Aurigon’s Point of View on the Safety Assessment of Cell Based Therapies – An Experience Based on the Participation in 15 ATMPs Projects

            Emmanuelle Cornali

           

PART II          LIVER DISEASES

3          Pre-Conditioning of the Liver for Efficient Repopulation by Primary Hepatocyte Transplants

            Petra Krause, Margret Rave–Fraenk, Hans Christiansen, Sarah Koenig

4          Age-Dependent Hepatocyte Transplantation for Functional Liver Tissue Reconstitution

            Peggy Stock   

5          Treatment of NASH with Human Mesenchymal Stem Cells in the Immunodeficient Mouse         

Sandra Winkler, Bruno Christ           

6          The in vivo Evaluation of the Therapeutic Potential of Human Adipose Tissue-Derived Mesenchymal Stem Cells for Acute Liver Disease

Takeshi Katsuda, Hayato Kurata, Rie Tamai, Agnieszka Banas, Tsuyoshi Ishii, Shumpei Ishikawa, and Takahiro Ochiya

7          A Mouse Model of Liver Injury to Evaluate Paracrine and Endocrine Effects of Bone Marrow Mesenchymal Stem Cells

Chiung-Kuei Huang, Soo Ok Lee, Jie Luo1, RongHao Wang, Qiang Dang, Chawnshang Chang  

8          Animal Models to Test hiPS-Derived Hepatocytes in the Context of Inherited Metabolic Liver Diseases

Mathilde Dusséaux, Sylvie Darche and Hélène Strick-Marchand    

9          Support of Hepatic Regeneration by Trophic Factors from Liver-Derived Mesenchymal Stromal/Stem Cells

Suomi M.G. Fouraschen, Sean R.R. Hall, Jeroen de Jonge and Luc J.W. van der Laan

 

PART III CARDIOVASCULAR DISEASES

 10        Assessment of Functional Competence of Endothelial Cells from Human Pluripotent Stem Cells in Zebrafish Embryos

            Valeria V. Orlova, Yvette Drabsch, Peter ten Dijke and Christine L. Mummery

11        Stem Cell Therapy for Necrotizing Enterocolitis: Innovative Techniques and Procedures for Pediatric Translational Research

            Jixin Yang, Yanwei Su and Gail E. Besner   

12        Exploring Mesenchymal Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury

Stefania Bruno, Giovanni Camussi    

13        Angiogenesic Properties of Mesenchymal Stem Cells in a Mouse Model of Limb Ischemia

            Sang Won Han

14        Methods to Assess Intestinal Stem Cell Activity in Response to Microbes in Drosophila melanogaster

            Philip L. Houtz and Nicolas Buchon

           

PART IV CONNECTIVE AND CONTRACTILE TISSUE

 15        Muscle Pouch Implantation: An Ectopic Bone Formation Model

Greg Asatrian, Le Chang, Aaron W. James

 

16        Bone Defect Repair in Mice by Mesenchymal Stem Cells

            Sanjay Kumar

17        Generation of Osteoporosis in Immune-Compromised Mice for Stem Cell Therapy

            Reeva Aggarwal, Vincent J. Pompili and Hiranmoy Das      

18        Application of Stem Cells for the Treatment of Joint Disease in Horses

            Walther Brehm, Janina Burk, Uta Delling

19        Adipogenic Fate Commitment of Muscle-Derived Progenitor Cells: Isolation, Culture and Differentiation

Anne-Marie Lau, Yu-Hua Tseng, and Tim J. Schulz

20        Skeletal Muscle Stem Cells for Muscle Regeneration

Johnny Kim and Thomas Braun

           

PART V          NEUROLOGICAL DISEASES

 21        Bone Marrow Stromal Stem Cells Transplantation in Mice with Acute Spinal Cord Injury

            Virginie Neirinckx, Bernard Rogister, Rachelle Franzen, Sabine Wislet-Gendebien

22        Histological Characterisation and Quantification of Cellular Events Following Neural and Fibroblast(-Like) Stem Cell Grafting in Healthy and Demyelinated CNS Tissue

Jelle Praet, Eva Santermans, Kristien Reekmans, Nathalie de Vocht, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Zwi Berneman, Niel Hens, Annemie Van der Linden, Peter Ponsaerts 

23        Improvement of Neurological Dysfunctions in Aphakia Mice, a Model of Parkinson’s Disease, after Transplantation of ES Cell-Derived Dopaminergic Neuronal Precursors

            Sangmi Chung, Jisook Moon, Kwang-Soo Kim        

24        Methods for Assessing Regenerative Responses of Neural Tissue

            Steven W. Poser, Maria Adele Rueger, and Andreas Androutsellis-Theotokis

           

25        Mesenchymal Stem Cell-Based Therapy in a Mouse Model of Experimental Autoimmune Encephalomyelitis (EAE)

Annie C. Bowles, Brittni A. Scruggs, Bruce Bunnell           

26        Analysis of the Neuroregenerative Activities of Mesenchymal Stem Cells in Functional Recovery after Rat Spinal Cord Injury

Akihito Yamamoto, Kohki Matsubara, Fumiya Kano, Kiyoshi Sakai          

 

PART VI        IMMUNEMODULATION BY STEM CELLS

 27        Therapeutic Application of Mesenchymal Stromal Cells in Murine Models of Inflammatory Bowel Disease

Elena Gonzalez-Rey and Mario Delgado

28        Mesenchymal Stem Cells Attenuate Rat Graft-versus-Host Disease

            Masayuki Fujino, Ping Zhu, Yusuke Kitazawa, Ji-Mei Chen, Jian Zhuang, and Xiao-Kang Li

29        Assessment of Anti-Donor T Cell Proliferation and Cytotoxic T Lymphocyte-Mediated Lympholysis in Living Donor Kidney Transplant Patients

            Aruna Rakha, Marta Todeschini, Federica Casiraghi

30        Modulation of Autoimmune Diseases by iPS Cells

            Fengyang Lei, Rizwanul Haque, Xiaofang Xiong and Jianxun Song           

31        A Chimeric Mouse Model to Study Immunopathogenesis of HCV Infection

            Moses T. Bility, Anthony Curtis and Lishan Su