Angiogenesis and Direct Myocardial Revascularization

ISBN-13: 9781588291530 / Angielski / Twarda / 2005 / 372 str.

Roger J. Laham; Roger J. Laham; Donald S. Baim

Opis

An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.

Recenzje

"This book masterfully and authoritatively blends expert opinion with quality scientific research to provide specialists with insight into current treatment options for end-stage ischemic patients and future possibilities." - Doody's Health Sciences Book Review Journal

"This book...summarizes this topic very well." -American Journal of Cardiology

Spis treści

No-Option Patients: A Growing Problem Roger J. Laham and Donald S. Baim Transcriptional Regulation of Angiogenesis Peter Oettgen Preclinical Models and Experience to Date Aysegul Yegin and Nicolas A. Chronos The Coronary Microcirculation and Angiogenesis Pierre Voisine, David G. Harrison, and Frank W. Sellke Local and Regional Vascular Delivery for Therapeutic Angiogenesis and Myogenesis Erik T. Price, Alan C. Yeung, and Mehrdad Rezaee Imaging Angiogenesis: A Guide for Clinical Management and Therapeutic Trials Justin D. Pearlman Myocardial Angiogenesis: Protein Growth Factors Kwang Soo Cha, Robert S. Schwartz, and Timothy D. Henry Gene Therapy for Angiogenesis in the Treatment of Cardiovascular and Peripheral Arterial Disease Pinak B. Shah, Kapildeo Lotun, and Douglas W. Losordo Therapeutic Angiogenesis in Peripheral Arterial Disease: Current Approaches and Future Directions Richard E. Waters and Brian H. Annex Bone Marrow Cell Transplantation for Myocardial Regeneration and Therapeutic Angiogenesis Hung-Fat Tse, Pui-Yin Lee, and Chu-Pak Lau Transplantation of Embryonic Stem Cells for Myocardial Regeneration and Angiogenesis Yong-Fu Xiao, Jiang-Yong Min, and James P. Morgan Skeletal Myoblast Transplantation for Cardiac Repair Audrey Rosinberg, Jamal S. Rana, and Roger J. Laham Transmyocardial Laser Revascularization Keith A. Horvath Index

Blurb

Despite the rapid progress in surgical and catheter-based revascularization, an alternative treatment strategy is needed for the ever-increasing number of patients who are either not candidates for these therapies or remain symptomatic after revascularization and maximal ongoing medical treatment. In Angiogenesis and Direct Myocardial Revascularization, an interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. In their assessments, the authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.
Authoritative and state-of-the-art, Angiogenesis and Direct Myocardial Revascularization provides all internists, cardiologists, vascular disease specialists, scientists, and industry with a highly effective scientific and clinical basis for helping patients with end-stage ischemic heart disease, peripheral vascular disease, and congestive heart failure.