Angiogenesis Modulations in Health and Disease: Practical Applications of Pro- And Anti-Angiogenesis Targets

ISBN-13: 9789400764668 / Angielski / Twarda / 2013 / 206 str.

Shaker A. Mousa; Paul J. Davis; Shaker A. Mousa

Opis

This book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. There is in-depth coverage of preclinical and clinical methods and models, investigational status, and clinical applications. The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in research and development of angiogenesis modulating targets.

Spis treści

Preface. 1. Angiogenesis assays: an appraisal of current techniques. 2. Survey of pro-angiogenesis strategies. 3. Angiogenesis modulation by arachidonic acid – derived lipids: positive and negative regulators of angiogenesis. 4. Pro-angiogenic activity of thyroid hormone analogues: Mechanisms, physiology and clinical prospects. 5. Actions of steroids and peptide hormones on angiogenesis. 6. Role of non-neuronal nicotinic acetylcholine receptors in    angiogenesis modulation. 7.  Catecholamine neurotransmitters: an angiogenic switch in the tumor microenvironment. 8. Impact of nanotechnology on therapeutic angiogenesis. 9. Survey of anti-angiogenesis strategies. 10. Tetraiodothyroacetic acid (tetrac), nanotetrac and anti-Angiogenesis. 11. Integrin antagonists and angiogenesis. 12. Anti-angiogenesis therapy as an adjunct to chemotherapy in oncology. 13. Anti-vegf strategies in ocular angiogenesis- mediated disorders, with special emphasis on age-related macular degeneration. 14. Application of nanotechnology to targeting tumor angiogenesis for therapeutic benefit. 15. Biomarkers of response and resistance to anti-angiogenic treatment.16. Speculations on new directions in which angiogenesis may proceed. Index.