Angiogenesis: From the Molecular to Integrative Pharmacology

ISBN-13: 9780306463754 / Angielski / Twarda / 2000 / 382 str.

Michael E. Maragoudakis

Opis

Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece.
Angiogenesis, as a vastly complex biological process, has challenged researchers from all basic scientific disciplines, including pharmacology, biochemistry, physiology, embryology and anatomy. The significance of this phenomenon for the study of disease states has also interested clinicians from a number of specialist fields. This multidisciplinary work reflects the growth of awareness of concepts such as angiogenesis based therapy, the enormous therapeutic and commercial potential of which has attracted major research and investment in recent years. This volume, which aims to bridge the gap between basic and clinical methodology and understanding, presents the most up-to-date developments in this field.

Spis treści

Introductory Comments; M. Maragoudakis Angiogenic Factors and their receptors Examining New Models for the Study of Autocrine and Paracrine Mechanisms of Angiogenesis Through FGF2- Transfected Endothelial and Tumour Cells; M. Presta, et al. Tie-1 Receptor Tyrosine Kinase Endomain Interaction with SHP2: Potential Signalling Mechanisms and Roles in Angiogenesis; M. Marron, et al. On the Mechanism(s) of Thrombin Induced Angiogenesis; M. Maragoudakis, N. Tsopanoglou. Endothelial Receptor Tyrosine Kinases Involved in Blood Vessel Development and Tumor Angiogenesis; G. Breier. Ontogeny of the Endothelial System in the Avian Model; L. Pardanaud, F. Dieterlen-LiÚvre. Regulation of Angiogenesis and Transduction Mechanisms Involved The Role of Pericytes in Controlling Angiogenesis in vivo; S. Egginton, et al. Insights into the Vasodilation of Rat Retinal Vessels Evoked by Vascular Endothelial Growth Factor121 (VEGF121); H. Hassessian. Signal Transduction and Transcriptional Regulation of Angiogenesis; Y. Sato, et al. Differential Contribution of Bradykinin Receptors in Angiogenesis; L. Morbidelli, et al. Sensitivity of Different Vascular Beds in the Eye to Neovascularization and Blood-Retinal Barrier Breakdown in VEGF Transgenic Mice; S. Vinores, et al. Revascularization of Ischemic Tissues with SIKVAV And Neuro-Peptide Y (NPY); D. Grant, Z. Zukowska. Cellular Effects and Signalling Pathways Activated by the Anti-Coagulant Factor, Protein S, In Vascular Cells; C. Kanthou, O Benzakour. Role of Extracellular Matrix and Adhesion Molecules in Angiogenesis. Targeting Integrins &agr;v&bgr;3 and&agr;v&bgr;5 for Blocking Tumor-Induced Angiogenesis; C. Kumar, et al. Suppression of Human Microvascular Endothelial Cell Invasion and Morphogenesis with Synthetic Matrixin Inhibitors; M-C Jia, et al. Inhibitors of Angiogenesis and their Mechanisms of Action. Tunicamycin Inhibits Capillary Endothelial Cell Proliferation by Inducing Apoptosis; J.Martinez, et al. The Characterization of Angiogenesis Inhibitor from Shark Cartilage; J. Liang, K-P. Wong. Quantitative Assays for the Chick Chorioallantoic Membrane; W. Thompson, A. Reid. Angiogenesis and Malignant Transformation. MYCN Oncogene and Angiogenesis: Down-Regulation of Endothelial Growth Inhibitors in Human Neuroblastoma Cells; E. Hatzi, et al. From Hyperplasia to Neoplasia and Invasion: Angiogenesis in the Colorectal Adenoma Carcinoma Model; L. Kaklamanis, et al. Tumor Angiogenesis, Macrophages and Cytokines; H. Bando, M. Toi. Microvessel Density, Thymidine Phosphorylase Expression and Resistance of Head and Neck Cancer to Chemo-Radiotherapy; M. Koukourakis. Differential Expression of Angiogenic and of Vascular Survival Factors in Non-Small Cell Lung Cancer (NSCLC); A. Gatromanolaki. Thymidine Phosphorylase Activity in Normal, Hyperplastic and Neoplastic Endometrium&endash;Correlation with Intratumoral Angiogenesis; E. Sivridis. Preclinical Developments of Angiogenesis Inhibitors. Inhibition of VEGF Signal Transduction; S. Wedge, D. Ogilvie. Combretastatins: Novel Vascular Targeting Drugs for Improving Anti-Cancer Therapy; M. Horsman, et al. Clinical Applications. Therapeutic Angiogenesis for Ischemic Heart Disease; A. Helisch, J. Ware. Abstracts of Posters. Participants' Photo. List of Participants. Index.