Androgens in Health and Disease

ISBN-13: 9781617373145 / Angielski / Miękka / 2010 / 448 str.

Carrie Bagatell; William J. Bremner

Opis

Authoritative researchers and clinicians review our latest understanding of andrology in both basic science and clinical medicine. Topics range from explaining the biology of androgens-from several different perspectives-to illuminating their role in the development and modulation of physiologic systems. Authors demonstrate in a number of cases that testosterone can be a useful adjunct to the treatment of a variety of disease states. Other chapters consider important topics such as androgens use in athletes, the potential of androgens to improve physical function and quality of life in older men, and androgens as potential male contraceptives.

Spis treści

I. General Andrology Testosterone Synthesis, Transport, and Metabolism Stephen J. Winters and Barbara J. Clark Androgen Action Terry R. Brown Hypogonadism in Men: An Overview Stephen R. Plymate Dihydrotestosterone and 5a-Reductase: Normal Physiology and Inhibition Paul R. Sutton, John K. Amory, and Richard V. Clark Estrogen Action in Males: Insights Through Mutations in Aromatase and Estrogen-Receptor Genes Jonathan Lindzey and Kenneth S. Korach Alterations of Androgen Action Caused by Mutation of the Human Androgen Receptor Michael J. McPhaul Androgen Excess Disorders in Women Richard S. Legro Androgen Pharmacology and Delivery Systems Christina Wang and Ronald S. Swerdloff II. Androgen Effects on Physiologic Systems Androgen Signaling in Prostatic Neoplasia and Hyperplasia Marco Marcelli, Dolores J. Lamb, Nancy L. Weigel, and Glenn R. Cunningham Androgens and Coronary Artery Disease Frederick C. W. Wu and Arnold von Eckardstein Androgens and Bone Anne M. Kenny and Lawrence G. Raisz Androgens and the Hematopoietic System Shehzad Basaria and Adrian S. Dobs Androgens and Body Composition Laurence Katznelson Androgens and Sexual Function in Men and Women John Bancroft Androgens and Cognition Monique M. Cherrier and Suzanne Craft III. Applied Andrology Androgen Treatment of the Hypogonadal Male Alvin M. Matsumoto Androgens and Puberty Erick J. Richmond and Alan D. Rogol Androgens as Anabolic Agents Shalender Bhasin, Linda J. Woodhouse, and Thomas W. Storer Androgens and Male Contraception John K. Amory Androgens in Primary Care Bradley D. Anawalt Index

Blurb

In recent years, medical researchers have demonstrated that androgens, both naturally occurring and synthetic, influence a myriad of physiological functions and can also be used therapeutically in a wide variety of clinical settings. In Androgens in Health and Disease, an authoritative panel of researchers and clinicians review our latest understanding of andrology in both basic science and clinical medicine. Topics range from explaining the biology of androgens-from several different perspectives-to illuminating their role in the development and modulation of physiologic systems. The authors demonstrate how testosterone can be a useful adjunct to the treatment of a variety of disease states, particularly those in which catabolism and loss of muscle mass occur. Other chapters consider important topics such as androgen use in athletes, the potential of androgens to improve physical function and quality of life in older men, and androgens as potential male contraceptives. Of special interest is a presentation of recent advances in understanding the physiological and clinical effects of androgen excess and androgen deficiency in women.
Authoritative and wide-ranging, Androgens in Health and Disease offers both researchers and practicing clinicians a comprehensive survey of how, why, and where androgens exert their effects, as well as their therapeutic roles in a broad range of diseases.