Androgens and Androgen Receptor: Mechanisms, Functions, and Clini Applications

ISBN-13: 9781461354222 / Angielski / Miękka / 2012 / 503 str.

Chawnshang Chang

Opis

Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications.
Key topics covered include: -The discovery and cloning of the androgen receptor;
-Androgen receptor coregulators;
-Androgen related genes and their consensus DNA response elements;
-Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies;
-Cross-talk to other signal transduction systems;
-The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer.This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.

Spis treści

Preface. Editor. List of Contributors.1. Androgen Biosynthesis and Degradation; Bon-Chu Chung, Meng-Chun Hu. 2. Structural and Functional Analysis of the Androgen Receptor; C. Heinlein, Chawnshang Chang. 3. Signal Transduction Pathways Modulate Androgen. Receptor Transcriptional Activity; C. Heinlein, Chawnshang Chang. 4. Androgen Receptor Interacting Proteins Co-Activators and Co-Repressors; C. Heinlein, et al. 5. Nongenomic Androgen Action; C. Heinlein, Chawnshang Chang. 6. The role of 5alpha-Reductase in Prostate Disease and Male Pattern Baldness; J. Shimazaki. 7. Natural Products and Environmental Androgens/Antiandrogens; Ming-Hsien Wang, et al. 8. Androgens in Prostate Cancer and Benign Prostatic Hypoplasia; T. Brown. 9. The Expanded Poly-Q Length Within AR and AR Coregulator A1B1 And Their Clinical Implications; A. Hsing, et al. 10. Androgen Receptor with Expanded Poly-Q Length in SBMA (Kennedy Disease); Y. Kobayashi, G. Sobue. 11. Androgen Insensivity Syndrome (Testicular Feminization); H. Nawata, et al. 12. Androgens in Immunology and Autoimmune Diseases; N. Olsen, W. Kovacs. 13. Androgens in Penile Development, Penile Erection and Erectile Dysfunction; J. Chang, et al. 14. Androgens and the Androgen Receptor in Male Sex Development and Fertility; L. Collins, et al. 15. Androgens and Brain Function: Behavioral Perspectives; R. Handa, R. McGivern. 16. Androgens, Skeletal Homeostasis, and Osteoporosis; D. Vanderschueren, et al. 17. Androgens and Coronary Artery Disease; A. von Eckardstein, F. CW Wu. 18. Androgen Therapy in Nonendocrine Illnesses; D. Spratt. 19. Androgens and Androgen Receptor in Dermatology; S. Itami, et al. 20. Androgen Deficiency and Abnormality in Women; S. Davis, C. Jang. Index.

O autorze

Chawnshang Chang, Ph.D., is the George Hoyt Whipple Distinguished Professor at the University of Rochester.