1. Introduction 2. The Limbic System: An Eroding Concept in Perpetual Search for a Definition 3. The Anatomy of the Basal Forebrain 4. The Greater Limbic Lobe 5. Focus on the Anatomy of Basal Forebrain Macrosystems 6. Cerebellum as a Macrosystem 7. Cooperation and Competition Among Macrosystems 8. Macrosystems in Motion, Emotion and Neuropsychiatric Illness 9. Macrosystems as a Fundamental Organizing Principle of Vertebrate Brain