Analysis of Mutation-promoting Mechanism Based on Big Data

ISBN-13: 9786203040487 / Angielski / Miękka / 80 str.

Jianhong Sun

Opis

To test and further explore the factors of mutation-promoting, a large number of experimental DNA samples from five populations (Africa, America, Europe, East Asia and South Asia) were subjected to statistical analysis in this book. The mainly research works are as follows:a. Explore the changing trend of GC content of the human genome under the influence of mutations.b. Assess whether the high mutation rate of C->T (C mutation is T, the same below) caused by CpG methylation will cause the CpG in the genome to be depleted.c. Explore the influence of context sequence on relative mutation rate.d. Verify the "Indels (insertion/deletion) mutagenesis hypothesis".

O autorze

Sun, Jianhong Jian-Hong Sun received the Master's Degree in Computer Information System Program from the Assumption University, Thailand, in 2009. He is currently an associate professor in the Engineering College, Honghe University, China. His current research interests include bioinformatics, data mining and big data analytics.