Analysis of Eplarestat-Pragabalin by Rp-HPLC

ISBN-13: 9786200505552 / Angielski / Miękka / 2020 / 100 str.

Ranabir Chanda

Opis

A basic, Accurate, exact strategy was produced for the concurrent estimation of the Epalrestat and Pregabalin in Tablet dose shape. Chromatogram was go through Std Kromasil 250 x 4.6 mm, 5m. Portable stage containing Buffer: Acetonitrile taken in the proportion 60:40 was pumped through section at a stream rate of 1 ml/min. Cradle utilized as a part of this technique was 0.1% OPA support. Temperature was kept up at 25°C. Advanced wavelength chose was 274.0 nm. Maintenance time of Epalrestat and Pregabalin were observed to be 2.520 min and 3.745 min. %RSD of the Epalrestat and Pregabalin were and observed to be 0.4% and 0.8% separately. %Recovery was acquired as 99.87% and 99.55% for Epalrestat and Pregabalin individually. LOD, LOQ esteems got from relapse conditions of Epalrestat and Pregabalin were 0.153, 0.464 and 0.376, 1.139 separately. Relapse condition of Epalrestat is y = 5471.4x+18850, and y = 4052.9x+4585.1 of Pregabalin. Maintenance times were diminished and run time was diminished, so the strategy created was straightforward and efficient that can be received in customary Quality control test in Industries.

O autorze

Chanda, Ranabir
Prof. (Dr.) Ranabir Chanda is working as principal at Sana College of Pharmacy, Kodad, Telangana, India. He has been working in different field of pharmacy profession including academic and corporate sector for 25 years. He is an author of more than 100 articles in different national and international journals.