Analysis of Drugs of Abuse

ISBN-13: 9781493985784 / Angielski / Twarda / 2018 / 231 str.

Rabi A. Musah

Opis

This volume features a comprehensive set of protocols featuring a range of both old and new technologies that can be used to analyze drugs of abuse, including prescription drugs, new psychoactive substances and psychoactive plants.

Spis treści

1.      Color Tests for the Preliminary Identification of New Psychoactive Substances

Kaitlyn Toole, Morgan Philp, Nadine Krayem, Shanlin F, and Ronald Shimmon

 

2.      Illicit and Counterfeit Drug Analysis by Morphologically Directed Raman Spectroscopy

Andrew C. Koutrakos, Pauline E. Leary, and Brooke W. Kammrath

 

3.      Analysis of Drugs of Abuse by Gas Chromatography-Mass Spectrometry (GC-MS)

Thomas A. Brettell and Benny J. Lum

 

4.      Towards Confirmatory On-site Real-Time Detection of Emerging Drugs Using Portable Ultrafast Capillary Electrophoresis Mass Spectrometry

Mehdi Moini

 

5.      Use of DART-TOF for Screening Drugs of Abuse

Robert R. Steiner

 

6.      Confirmation of Pharmaceutical Identifiers via DART-TOF

Jacob Easter

 

7.      UPLC-Orbitrap® Screening for Over 35 Drugs of Abuse and Metabolites in Biological Fluids Under 10 Minutes

Eshwar Jagerdeo and Jason E. Schaff

 

8.      Sensitivity Enhancement in Capillary Electrophoresis Using Magnetic Particles as Solid-phase Extraction Sorbents for the Determination of Drugs of Abuse in Urine

Tatiana Baciu, Francesc Borrull, Carme Aguilar, and Marta Calull

 

9.      High Throughput Extraction and Detection of Drugs in Urine:  Parallel Sampling with Solid-Phase Microextraction (SPME) Fibers Coupled with Direct Analysis in Real Time - Mass Spectrometry (DART-MS) Detection

Frederick Li and Brian Musselman

 

10.  Analysis of Drugs of Abuse in Hair Samples by Ultra High Performance Liquid Chromatography/Tandem Mass Spectrometry (UHPLC-MS/MS)

Daniele Di Corcia, Alberto Salomone, and Enrico Gerace

 

11.  Comprehensive Drug Screening by Thermal Desorption and Pyrolysis Combined with Direct Analysis in Real Time-Mass Spectrometry (TDP/DART-MS)

Hiroko Abe, Chikako Takei, Motoshi Sakakura, Daisuke Yajima, and Hirotato Iwase

 

12.  Detection of Diagnostic Plant-derived Psychoactive Biomarkers in Fingerprints by MALDI-SpiralTOF-MS

Cameron M. Longo and Rabi A. Musah

13.  Matrix-assisted Laser Desorption Ionization Imaging Mass Spectrometry of Drug Distributions in Mouse Brain Tissue by High-resolution Time-of-flight Mass sSectrometry

Takaya Satoh, Ayumi Kubo, and Hisanao Hazama

 

14.  Estimation of Community Usage of Drugs Utilizing Sewage

Bikram Subedi

 

15.  LC-MS-MS Method Development and Analysis of Stimulants, Opiates, Synthetic Opiates, PCP, and Benzodiazepines in Wastewater. Preponderance of these Drugs During Football Games

Waseem Gul, Shahbaz W. Gul, Brandon Stamper, Murrell Godfrey, and Mahmoud A. ElSohly

 

16.  Analysis of Illicit Drugs in Wastewater Using High Performance Liquid Chromatography – Electrospray Ionization – Tandem Mass Spectrometry (HPLC-ESI-MS/MS)

Katelyn S. Foppe and Bikram Subedi

 

17.  Analysis of Trace Drugs of Abuse by Direct Analysis in Real Time (DART) Mass Spectrometry

David D. Cunningham

 

18.  A Rapid, High-throughput Validated Method for the Quantification of Atropine in Datura stramonium Seeds Using Direct Analysis in Real Time-high Resolution Mass Spectrometry (DART-HRMS)

Ashton D. Lesiak, Kristen L. Fowble, and Rabi A. Musah

 

19.  Utilizing Direct Analysis in Real Time-high Resolution Mass Spectrometry-derived Dark Matter Spectra to Classify and Identify Unknown Synthetic Cathinones

Kristen L. Fowble and Rabi A. Musah

Blurb

This volume features a comprehensive set of protocols featuring a range of both old and new technologies that can be used to analyze drugs of abuse, including prescription drugs, new psychoactive substances and psychoactive plants. Chapters guide readers through the application of color tests, light microscopy-based particle imaging, GC-MS, Raman spectroscopy, capillary electrophoresis, ultra-high performance LC-tandem MS, DART-MS, MALDI-mass spectrometry imaging, LC-MS/MS and HPLC-ESI-MS/MS to the analysis of abused drugs in wastewater, hair, urine and plant-derived materials, among other matrices. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Analysis of Drugs of Abuse aims to ensure successful results in the further study of this vital field.