Analysis of Complex Diseases: A Mathematical Perspective

ISBN-13: 9780367379001 / Angielski / Miękka / 2019 / 200 str.

Phd Wang

Opis

Focusing on diseases related to cellular energy metabolism, such as cancer and diabetes, this book presents a holistic perspective for illuminating the molecular mechanisms of these diseases and the evolutionary underpinning of their simultaneous epidemics. It demonstrates the importance of physical thinking and mathematical analysis in understanding complex systems. Taking an interdisciplinary look at this translational subject, the book explains how mathematical modeling and analysis are critical to the future of diagnostics and therapeutics in medicine.

Spis treści

Organismal Level: What Is Required. Food Intake and Energy Metabolism. Glucose Homeostasis. Optimal Glucose Homeostasis. Bistability as a Fundamental Phenomenon. Molecular Level: What Can Be Provided? Molecular Biology. Biomolecular Network. PI3K-AKT-TOR Pathway. Mathematical Analysis of Complex Diseases. Diseases Related to Metabolism. Mathematical Modeling of the PI3K-AKT-TOR Pathway. Fundamental Decomposition. Normal Phenotype. Disease Phenotypes. Tao of Diseases. References. Abbreviations. Appendix A Optimization of Insulin Action. Appendix B Derivation of the Master Equation of AKT Activation. Appendix C Singularity Theory. Appendix D Analysis of the Simplified Master Equation. Appendix E Analysis of the Master Equation. Index.

O autorze

Guanyu Wang obtained one PhD (in engineering) from Zhejiang University, China, in 1998 and one PhD (in medical sciences) from the University of Cologne, Germany, in 2005. As a postdoctoral fellow, he was initially at the School of Health Information of the University of Texas Health Science Center at Houston and then at the Department of Bioengineering, Rice University. He was an assistant professor of Pathology and Laboratory Medicine at the University of Texas Health Science Center at Houston and then an assistant professor of Physics at George Washington University. He is now an associate professor of biology at South University of Science and Technology of China, located in the city of Shenzhen.