An unexpected role for decorin in delayed type hypersensitivity

ISBN-13: 9783330026810 / Angielski / Miękka / 2017 / 124 str.

Negia Abdullah Emtawel Mohamed

Opis

Decorin is a member of small leucine-rich repeat proteoglycans. It is ubiquitously expressed, primarily in the skin. It participates in extracellular matrix assembly. It plays a role in cell adhesion and migration processes directly and indirectly via interactions with membrane receptors. Delayed-type hypersensitivity (DTH) response in mice is widely used as a model of allergic contact dermatitis, allowing the study of cell-mediated immune response in vivo. We demonstrated that decorin modulates oxazolone-induced DTH reactions in mice. These findings were associated with an increased percentage of circulating decorin-deficient neutrophils.Decorin-deficient polymorphonuclear cells (PMNs) display an increased adhesion to endothelial cells in vitro compared to the wild-type. This is consistent with increase adhesion of Decorin-deficient leukocytes to the blood vessel wall in our DTH model in vivo. Collectively, absence of decorin exerts a protective effect on oxazolone-induced contact hypersensitivity reactions. This may lead to the development of new strategies in the treatment of contact dermatitis

O autorze

Dr. Negia Abdullah Emtawel Mohamed, PHD Holder in Medical Biochemistry is currently working as an Assistant Professor in Benghazi University. Having an extensive experience, she has written many articles and attended many conferences in the field of Medical Biochemistry