An Introduction to Systems Biology: Design Principles of Biological Circuits

ISBN-13: 9781439837177 / Angielski / Miękka / 2019 / 342 str.

Uri Alon

Opis

Written for students and researchers in systems biology, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological networks, highlighting simple, recurring circuit elements that make up the network. Rigorously classroom-tested, it contains new additions as well as corrections and revisions for better flow. This edition includes four new chapters: Perfect Robustness, Scaling in Development, Noise and Variability in Biological Circuits, and Evolution of Modularity. It also doubles the number of exercises and adds an appendix.

Spis treści

Part 1: Network Motifs. 1. Transcription Networks: Basic Concepts. 2. Autoregulation: A Network Motif. 3. The Feedforward Loop Network Motif. 4. Temporal Programs and the Global Structure of Transcription Networks. 5. Positive Feedback, Bistability, and Memory. 6. How to Build a Biological Oscillator. Part 2: Robustness. 7. Kinetic Proofreading and Conformational Proofreading. 8. Robust Signaling by Bifunctional Components. 9. Robustness and Bacterial Chemotaxis. 10. Fold-Change Detection. 11. Dynamical Compensation and Mutant Resistance in Tissues. 12. Robust Spatial Patterning in Development. Part 3: Optimality. 13. Optimal Gene Circuit Design. 14. Multi-Objective Optimality in Biology. 15. Modularity. Appendix A: The Input Functions of Genes: Michaelis-Menten and Hill Equations. Appendix B: Multi-Dimensional Input Functions. Appendix C: Graph Properties of Transcription Networks. Appendix D. Noise in Gene Expression.

O autorze

Uri Alon is the Abisch-Frenkel professor of systems biology at the Weizmann Institute of Science; https://www.weizmann.ac.il/mcb/UriAlon/homepage