An Introduction to Genetic Epidemiology

ISBN-13: 9781861348982 / Angielski / Twarda / 2011 / 256 str.

Lyle J Palmer

Opis

Genetic epidemiology is a very rapidly developing field that has acquired a central role in modern biomedical science. Until now there has been no comprehensive introductory text for students and academics who do not have specialised training in statistics or genetics. This book begins with a primer in human molecular genetics and then examines standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field. Among much else, the book contains discussion of the public health aspects of the new genetics, and of epidemiological methods for studying genes and environmental factors in complex diseases.Written by leading international experts and supplemented by a glossary and in-chapter guides to further reading, this essential textbook will be widely welcomed by teachers and students on many courses internationally.

Spis treści

Key concepts in genetic epidemiology ~ Paul R Burton, Martin D Tobin and John L Hopper; Genetic linkage studies ~ M Dawn Teare and Jennifer H. Barrett; Genetic association studies ~ Heather J. Cordell and David G. Clayton; Mapping complex disease genes using linkage disequilibrium and genome-wide association scans ~ Lyle J Palmer, Nicholas J Timpson, David M Evans, George Davey Smith and Lon R Cardon; A question of standards: what makes a good genetic association study? ~ Andrew T Hattersley and Mark I McCarthy; Biobanks and biobank harmonisation ~ Paul R Burton, Isabel Fortier, Mylene Deschênes, Anna Hansell and Lyle J Palmer; Population health aspects of genetic epidemiology: genomic profiling, personalised medicine, and Mendelian randomisation ~ George Davey Smith, Shah Ebrahim, Sarah Lewis and Lyle J Palmer.