An Introduction to Biomaterials

ISBN-13: 9781439812563 / Angielski / Twarda / 2011 / 644 str.

Jeffrey O. Hollinger

Opis

A practical road map to the key families of biomaterials and their potential applications in clinical therapeutics, Introduction to Biomaterials, Second Edition follows the entire path of development from theory to lab to practical application. It highlights new biocompatibility issues, metrics, and statistics as well as new legislation for intellectual property. Divided into four sections (Biology, Biomechanics, Biomaterials Interactions; Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property; Biomaterials Compositions; and Biomaterials Applications), this dramatically revised edition includes both new and revised chapters on cells, tissues, and signaling molecules in wound healing cascades, as well as two revised chapters on standardized materials testing with in vitro and in vivo paradigms consistent with regulatory guidelines. Emphasizing biocompatibility at the biomaterial-host interface, it investigates cell-cell interactions, cell-signaling and the inflammatory and complement cascades, specific interactions of protein-adsorbed materials, and other inherent biological constraints including solid-liquid interfaces, diffusion, and protein types. Unique in its inclusion of the practicalities of biomaterials as an industry, the book also covers the basic principles of statistics, new U.S. FDA information on the biomaterials-biology issues relevant to patent applications, and considerations of intellectual property and patent disclosure. With nine completely new chapters and 24 chapters extensively updated and revised with new accomplishments and contemporary data, this comprehensive introduction discusses 13 important classes of biomaterials, their fundamental and applied research, practical applications, performance properties, synthesis and testing, potential future applications, and commonly matched clinical applications. The authors include extensive references, to create a comprehensive, yet manageable didactic work that is an invaluable desk references and instructional text for undergraduates and working professionals alike.

Spis treści

Consensus Definitions, Fundamental Concepts, and a Standardized Approach to Applied Biomaterials Sciences. Biology, Biomechanics, Biomaterial Interactions: Wound Healing Biology. Cutaneous Wound Pathobiology: Raison d’etre for Tissue Engineering. Osseous Wound Healing. Biology, Biomechanics, Biomaterial Interactions: Cellular Mechanics. Cell and Tissue Mechanobiology. Biology, Biomechanics, Biomaterial Interactions: Materials–Host Interactions. Cell–Material Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations. Host Response to Biomaterials. Protein Adsorption at the Biomaterial–Tissue Interface. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Standardized Materials Testing. In Vitro Testing of Biomaterials. Assessment of Biomaterials: Standardized In Vivo Testing. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Statistics. Basic Principles of Statistics: Considerations for Biomaterials Engineers. Therapy Development, Animal Testing, and Regulatory Issues. Fundamentals of Patenting for the Biomaterials Scientist. Biomaterials Compositions. Proteins and Amino Acid–Derived Polymers. Three-Dimensional Fibrin Constructs in Tissue Engineering. Biomedical Polyurethanes. Polymers Derived from l-Tyrosine. Poly(propylene Fumarate). Complex Polysaccharides: Chitosan and Alginate. Collagen: A Natural Biomaterial for Tissue Engineering. Polyphosphazenes. Biologically Active Glasses. Silk-Based Biomaterials: Biology, Properties, and Clinical Applications. Calcium-Based Bioceramics: Biology, Properties, and Clinical Applications. Biomaterials Applications. Tissue Engineering of Skin. Polymeric Biomaterials for Drug and Nucleic Acid Delivery. Orthopedic Prostheses and Joint Implants. Bone and Biomaterials. Functional Regeneration of Synovial Joints In Vivo: The Role of Biomaterials and Scaffold Design. Tissue Engineering, Biomaterials, and the Nervous System. Ligaments, Biomaterials, and Tissue-Engineering Opportunities. Cardiovascular Tissue Engineering and Biomaterials. Index.