An Information Technology Framework for Predictive, Preventive and Personalised Medicine: A Use-Case with Hepatocellular Carcinoma

ISBN-13: 9783319121659 / Angielski / Twarda / 2015 / 130 str.

Leonard Berliner; Heinz U. Lemke

Opis

This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact that the first three tasks will have on the management of HCC. An IT System for Personalized Medicine (ITS-PM) for HCC will provide the means to identify and determine the relative value of the wide number of variables, including clinical assessment of the patient -- functional status, liver function, degree of cirrhosis, and comorbidities; tumor biology, at a molecular, genetic and anatomic level; tumor burden and individual patient response; medical and operative treatments and their outcomes.

Spis treści

Preface

Chapter 1  Introduction
Leonard Berliner and Heinz U. Lemke 

Chapter 2  The Digital Patient Model and Model Guided Therapy
Leonard Berliner and Heinz U. Lemke

Chapter 3  Hepatocellular Carcinoma and Patient Assessment
Smruti Mohanty, Sid Verma, David Dosik, Hesham Hazin and Leonard Berliner

Chapter 4  Imaging in Hepatocellular Carcinoma: Radiologic Assessment
Irene Bargellini, Valentina Battaglia, Davide  Caramella and Carlo Bartolozzi

Chapter 5  Imaging in Hepatocellular Carcinoma: PET/CT
Giuseppe Esposito

Chapter 6  Personalized Chemotherapy for Hepatocellular Carcinoma
Hesham Hazin and  David Dosik 

Chapter 7  Surgical Treatment for Hepatocellular Carcinoma Smruti Mohanty, Leonard Berliner and Syed Shah

Chapter 8  Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies
Paul Morrison and Eric vanSonnenberg 

Chapter 9  Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Therapies
Eric vanSonnenberg and Leonard Berliner 

Chapter 10  Minimally Invasive Therapies for Hepatocellular Cancer: Catheter-Directed Therapies
Leonard Berliner and Smruti Mohanty 

Chapter 11  Radiation Oncology in the Treatment of Hepatocellular Carcinoma
Hani Ashamalla and Malcom D. Mattes 

Chapter 12  Design of an IT System for Hepatocellular Carcinoma
Leonard Berliner and Heinz U. Lemke 

Chapter 13  Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular Carcinoma
Leonard Berliner, Heinz U. Lemke, Hani Ashamalla and Smruti Moha