Alternative Mechanisms of Multidrug Resistance in Cancer

ISBN-13: 9781461598541 / Angielski / Miękka / 2012 / 281 str.

John A. Kellen

Opis

Nullius in verba. . . Truth will be tested not by words. Horace (Epistles) Few read introductions except for book reviewers, who want to take a shortcut and avoid reading the book itself. However, tradition requires that the preface make public why the book was written at all (this is not supposed to include powerful reasons such as augmenting the ego of the editor and authors). Frequently, the inflationary tendency to publish in verbose length is in conflict with market forces and interest. No doubt, multidrug resistance is a "fashionable" topic, but there are many fashions displayed on the cat-walk of scientific literature. One can rationalize that the forces driving our concern with multi drug resistance reflect the frustration of pharmaceutical companies and oncologists alike: as soon as a new anticancer drug enters clinical trials, cancer cells start eluding extinction with their elaborate and successful mechanisms. Many grants have been awarded and spent, only to confirm the futility of our efforts to defeat this cellular Darwinism. Our medical and scientific training makes it hard, if not impossible, to accept that the survival of a malignant cell, alone or as part of a tissue, is part of the continuance of life. Since exposure to noxious and lethal substances is unavoidable, cells have been forced to develop a multitude of mechanisms to prevent entry or accelerate exit of such materials from intracellular space.

Spis treści

1. Mechanisms of Multidrug Resistance.- 2. The Role of Glutathione S-Transferases in Drug Resistance.- 3. Pharmacology of Drug Transport in Multidrug Resistant Tumor Cells.- 4. The Multidrug Resistance-Associated Protein MRP.- 5. Topoisomerases in Multidrug Resistance.- 6. Genotoxicity of Topoisomerase II Inhibitors-Consequences of Chemotherapy.- 7. A Distinctive Multiple Drug Resistance Phenotype in Tumor Cells Exposed to X-Irradiation.- 8. Taxoids and Multidrug Resistance.- 9. The Contribution of Protein Kinase C to Multiple Drug Resistance in Cancer.- 10. Bcl-2 and Chemoresistance in Cancer.- 11. Molecular Interrelationships in Multidrug Resistance.- 12. Platinum Resistance in Human Carcinomas.- Perspectives.- Conclusions.