Alpha-1 Proteinase Inhibitor in Action: Roles and Mechanistic Insights : Structure Function Relationship of Alpha-1 Proteinase Inhibitor

ISBN-13: 9783659261770 / Angielski / Miękka / 2012 / 200 str.

Vivek Gupta; Veer Bala Gupta

Opis

Alpha 1 proteinase inhibitor, the archetypal member of the serpin superfamily is an acute phase protein and protects pulmonary tissues from gtatuitous elastase digestion and inhibits neutrophil elatase at sites of inflammation. In this book we have explained the structure function relationships of alpha 1 proteinase inhibitor. A detailed biochemical characterization and mechanism of multiple protease inhibition elucidated. Further, alpha 1 proteinase inhibitor interactions with negatively charged heparin have been localised in terms of specific residues involved and investigated in terms of both activation as well as conformational changes.

O autorze

Dr. Vivek Gupta and Dr. Veer Bala Gupta did their PhD in Biochemistry from the University of Mysore and have extensive researh experience in the field of protein chemistry and studying the neuroprotective mechanisms. Dr. Vivek works at Macqarie University as a research fellow. Dr. Veer Gupta is associated with Edith Cowen University as a lecturer.