Allergy and Allergic Diseases: The New Mechanisms and Therapeutics

ISBN-13: 9781617370267 / Angielski / Miękka / 2010 / 599 str.

Judah A. Denburg

Opis

Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field."

Recenzje

"The book presents a broad overview of the field at a level that is easy to understand. . .provides an advanced understanding of the current state of the field and leaves the reader receptive to new concepts and therapies for allergic disease that will soon be forthcoming"-Dale T. Umetsu, MD, PhD, review in the April 29, 1999 issue of The New England Journal of Medicine

"...an excellent book on allergy and allergic diseases....a carefully thought-out whole, starting with IgE mechanisms, environmental allergens, and the new "jungle hypothesis" of atopic disorders beginning in early childhood. The book then proceeds to cellular and molecular aspects of inflammation, highlighting the key points of the pathogenesis of allergy in different organs, and ending with the essentials of treatment." - Allergy

"The book certainly has the five main features described in the presentation: it is written by leading authorities in allergy research...it provides an updated comprehensive survey of the mechanisms of allergic diseases; it illustrates the cellular and molecular bases of allergy and asthma; it emphasizes pathogenesis and the relevance of mechanisms to clinical expression; it includes useful information on therapeutics and possibilities for drug discovery." - EACCI

Spis treści

Part I. Epidemiology/IGE. Molecular Mechanisms of Isotype Switching to IGE, Donata Vercelli. Cytokines and IGE Regulation, Juha Punnonen and Jan E. de Vries. Environmental Allergens, Thomas A. E. Platts-Mills, Judith A. Woodfolk, and Lisa M. Wheatley. Ontogeny of Allergy, Bengt Bjorksten. Part II. Inflammation: Cellular Aspects. The Role of the Bone Marrow in Allergic Disease, Mark D. Inman, Roma Sehmi, Paul M. O'Byrne, and Judah A. Denburg. The Role of Mast Cells in Inflammation and Homeostasis, Angus J. MacDonald, Fiona L. Wills, Tong-Jun Lin, and A. Dean Befus. Human Langerhans Cells, Thomas Bieber. Eosinophils, Redwan Moqbel and Paige Lacy. Role of Basophils in Allergic Reactions, Peter Valent. Neurogenic Inflammation in Allergic Disease, Peter J. Barnes. Inflammation: Th1/Th2 Cells, Sergio Romagnani. T-Cells in the Pathogenesis of Asthma and Allergic Diseases, Marc Humbert and Stephen R. Durham. Role of CD8+ T-Cells in the Regulation of Immunoglobulin E, Paul A. MacAry and David M. Kemeny. Airway Wall Structure, Peter K. Jeffery, Mariusz J. Gizycki, and Andrew V. Rogers. Epithelium, Mary H. Perdue and Derek M. McKay. Part III. Inflammation: Molecular Aspects. Proinflammatory Cytokines in Allergic Disease, Daniel L. Hamilos. Hemopoietic Cytokines: Function, Receptor, and Signal Transduction, Hirokazu Kurata and Ken-ichi Arai. Adhesion Receptors in Allergic Disease, Andrew J. Wardlaw. Cell/Cytokine Interactions, David H. Broide. Signaling in Mast Cells, Anthony P. Sampson and Martin K. Church. Signaling in Human Basophils, Donald MacGlashan, Jr. Eosinophil Signal Transduction, Hirohita Kita. Part IV. Pathogenesis. Pathogenesis of Allergic Rhinitis, Niels Mygind and Ronald Dahl. Pathogenetic Mechanisms of Urticaria, Allen P. Kaplan. Atopic Eczema, Johannes Ring, Ulf Darsow, and Dietrich Abeck. Pathogenesis of Asthma, Paul M. O'Byrne. Pathogenesis of Allergic Conjunctivitis, Sergio Bonini and Stefano Bonini. Part V. Therapeutics. Glucocorticoids (Corticosteroids),Christopher J. Corrigan. ß-Agonists, Harold S. Nelson. Sodium Cromglycate and Nedocromil Sodium, Alan M. Edwards, Alexis E. Harper, Ken Rainey, and Alan A. Norris. Airway Remodeling and Repair, Peter M. Hockey, Ratko Djukanovic, William R. Roche, and Stephen T. Holgate. Index.

Blurb

In Allergy and Allergic Diseases: The New Mechanisms and Therapeutics, a distinguished international panel of researchers and clinicians review the latest findings on the cellular and molecular foundations of allergic diseases, particularly those of the airway, skin, and bowel. The key topics treated span the range from epidemiology and the mechanisms of inflammation, to signaling in pathogenesis and allergic reactions. Each contributor treats the pathophysiology of allergy in various organ-based diseases and syndromes, emphasizing important new findings from cellular and molecular biology that illuminate these diseases, but also reveal important leads for the development of novel drugs and therapeutic strategies.

Allergy and Allergic Diseases: The New Mechanisms and Therapeutics highlights the interface between basic and clinical science in allergic disease. Its up-to-date, clinically relevant approach constitutes the new standard knowledge base in clinical immunology and allergy, not only for specialists, but also for internists, for scientists studying the cellular and molecular biology of inflammation and immunity, and for researchers focused on drug discovery and therapeutics. Authoritative and timely, Allergy and Allergic Diseases is clearly the today's indispensable new resource for all physicians and investigators seeking a deeper understanding of allergy in both its basic and clinical aspects.