Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March

ISBN-13: 9780124202269 / Angielski / Twarda / 2015 / 408 str.

Wahn, Hans Ulrich Sampson, Hugh A.

Opis

Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March provides valuable insights on the atopic diseases, including asthma, allergic rhinitis, atopic dermatitis, and food allergies, which have developed into major health problems in most parts of the world. As the natural history of these chronic diseases has been extensively studied, including their major genetic, environmental, and lifestyle determinants and potential protective factors, the book presents tactics on how pediatric allergists can provide early intervention. In addition, the book unites key, global experts in the field who summarize their collective, and current, knowledge of the early stage of the "Atopic March," along with novel ideas for potential options of prevention.

• Summarizes the current knowledge of the epidemiological, genetic, and cellular basis of allergic diseases
• Ideal reference for the study of allergies in young children, atopic dermatitis, allergic rhinitis, childhood asthma, and food allergies
• Provides landmark findings in the field of immunology and allergy development
• Fulfills the need for a book that focuses on primary and secondary allergy prevention, especially during the first years of life
• Unites key, global experts in the field who summarize their collective, and current, knowledge, along with novel ideas for potential options of prevention

Spis treści

1. Genes for allergic manifestation
2. Epigenetics
3. What have we missed already by birth
4. B Cell Development
5. Maturation of T cell functions
6. The innate immune system
7. Atopic dermatitis
8. Wheeze and asthma
9. Pollen allergy
10. Lung function
11. Breast -always best?
12. Novel routes for antiallergic vaccination
13. Novel ideas for antiallergic vaccines
14. Antiallergic treatment of the skin
15. Systemic pharmacotherapy
16. Antiviral strategies
17. Adverse reactions of the gut
18. Hydrolysate diets
19. Probiotics-Prebiotics
20. Microbial Compounds
21. Avoidance of allergens

O autorze

1970 Graduation at University of Heidelberg, MD-thesis

1971 - 1972 Postdoc at German Cancer Research Institute, Heidelberg

1972 - 1978 Clinical Training for Pediatrics and Allergology at University Children's Hospital Heidelberg

1978 - 1979 Research Fellow at National Institutes of Health (Clinical Immunology Section) in Bethesda, USA

1979 - 1981 University Children's Hospital, Heidelberg Habilitation (Member of the Faculty) Heidelberg, Senior Staff, Member at Children's Hospital Ruhr-University Bochum

1986 - 1998 Professor for Pediatric Pneumology and Immunology (C3) at Children's Hospital of Free University Berlin, Chief of Pediatric Pneumology Department, Chest Clinic Heckeshorn

1998 - 2012 Chair and Head of the department für Pediatric Pneumology and Immunology (C4), Charité, Berlin

Functions:

2003 - 2005 President of the European Academy of Allergy and Clinical Immunology

2003 - 2007 Associate Editor: European Respiratory Journal

2003 - 2009 Fachkollegiat of the Deutsche Forschungsgemeinschaft

2010 - 2012 Labor Berlin, Director for Allergy and Immunology

From 2010 Chief Editor: Pediatric Allergy and Immunology (PAI)

Publications: 450 original papers in peer reviewed journals, 30 books/book chapters

Hugh A Sampson, MD, is the Kurt Hirschhorn Professor of Pediatrics, the Dean for Translational Biomedical Sciences, PI and Director of Conduits; Institutes for Translational Sciences (CTSA), and the Director of the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai in New York City. Dr. Sampson completed his allergy/immunology fellowship training at Duke University in 1980 and was a faculty member in the Division of Allergy/Immunology at Duke University and then Johns Hopkins University before coming to Mount Sinai. Dr. Sampson's research interests have focused primarily on food allergic disorders including the immunopathogenic role of food hypersensitivity in atopic dermatitis and anaphylaxis, characterization of food allergens, and improved diagnostic tests and immunotherapeutic strategies for treating food allergies. Dr. Sampson is the PI of the NIH-sponsored Consortium on Food Allergy Research and an AADCRC program project conducting a number of clinical trials investigating novel therapies for the treatment of food allergy and investigating basic immunologic mechanisms associated with desensitization and the eventual development of tolerance. He has published over 400 articles and 60 book chapters on food allergic disorders and co-edited four books, and was elected to membership in the Institute of Medicine of the National Academies in 2003 for his research in food allergies. Dr. Sampson is past chairman of the Section on Allergy & Immunology of the American Academy of Pediatrics and the past-president of the American Academy of Allergy, Asthma and Immunology.