Allergic Contact Dermatitis: The Molecular Basis

ISBN-13: 9783642803338 / Angielski / Miękka / 2011 / 186 str.

Jean-Pierre Lepoittevin; David A. Basketter; An Goossens

Opis

Allergic Contact Dermatitis presents all up-to-date chemical and physio-chemical concepts for the study and understanding of allergic contact dermatitis (ACD). The book covers all aspects of ACD - skin penetration and metabolism, identification of sensitizers and hapten-protein interaction, including new concepts of increasing importance such as molecular recognition and quantitative structure-activity relationships. In addition, comprehensive references are provided, making this the most complete available text-book for dermatologists.
Allergic Contact Dermatitis reaches an equilibrium between fundamental concepts and clinical applications and thus presents an essential guideline to dermatologists, allergologists, biochemists and toxicologists.

Spis treści

1. Introduction.- 2. Immunological Aspects.- 3. Chemical Basis.- 4. Isolation and Identification of Contact Allergens.- 5. Skin Metabolism.- 6. Hapten-Protein Interactions.- 7. Molecular Basis for the Recognition of Haptens by T Lymphocytes.- 8. Structure-Activity Relationships for Contact Hypersensitivity.- 9. The Practical Approach.