Algebraic and Combinatorial Computational Biology

ISBN-13: 9780128140666 / Angielski / Miękka / 2018 / 434 str.

Raina Robeva; Matthew MacAuley

Spis treści

1. Multi-scale graph-theoretic modeling of bimolecular structures 2. DNA nanostructures: Mathematical design and problem encoding 3. Graphs associated with DNA rearrangements and their polynomials 4. Regulation of gene expression by operons: Boolean, logical, and local models 5. Modeling the stochastic nature of gene regulation: probabilistic Boolean networks 6. Inferring interactions in molecular networks via primary decompositions of monomial ideals 7. Analysis of combinatorial neural codes: an algebraic approach 8. Predicting neural network dynamics: insights from graph theory 9. Multistationarity in biochemical networks: Results, analysis, and examples 10. Optimization problems in phylogenetics: Polytopes, programming and interpretation 11. Clustering via self-organizing maps on biology and medicine 12. Toward revealing protein function: Identifying biologically relevant clusters with graph spectral methods

O autorze

Raina Robeva was born in Sofia, Bulgaria. She holds a PhD in Mathematics from the University of Virginia and has broad research interests spanning theoretical mathematics, applied probability, and systems biology. Robeva is the founding Chief Editor of the journal Frontiers in Systems Biology and the lead author/editor of the books An Invitation to Biomathematics (2008), Mathematical Concepts and Methods in Modern Biology: Using Modern Discrete Models (2013), and Algebraic and Discrete Mathematical Methods for Modern Biology (2015), all published by Academic Press. She is Professor of Mathematical Sciences and Director of the Center for Science and Technology in Society at Sweet Briar College. Matthew Macauley is an Associate Professor at Clemson University in South Carolina. Since finishing his PhD in Mathematics from the University of California, Santa Barbara, he has been a research visitor at the Biocomplexity Institute of Virginia Tech, the Institute for Systems Biology in Seattle, and the University of Southern Denmark. He has also taught internationally in both South Africa and Taiwan. Macauley has supervised two PhD and five MS students, as well as a number of undergraduate research students. With Raina Robeva, he has co-organized three faculty development workshops on teaching discrete and algebraic methods in mathematical biology to undergraduates.