Algae-Based Biopharmaceuticals

ISBN-13: 9783319812298 / Angielski / Miękka / 2018 / 166 str.

Sergio Rosales-Mendoza

Spis treści

The Biopharmaceuticals Field and Algae as Expression Hosts

 

Genetic Engineering Approaches for Algae

 

Algae-made Vaccines Targeting Human Diseases

 

Algae-made Vaccines Targeting Animal Pathogens

 

Algae-made Antibodies and Immunotoxins

 

Algae-made Cytokines and Growth Factors

 

Other Biopharmaceuticals Produced in Algae

 

Algae-made Nutraceuticals

 

Perspectives for the Algae-made Biopharmaceuticals Field

O autorze

Dr. Sergio Rosales-Mendoza is professor of Biotechnology and has worked in the area of biopharmaceuticals produced in low‐cost platforms for the past 10 years. Over his career, Dr. Rosales-Mendoza has published several scientific refereed articles in international high‐impact scientific journals. 

Blurb

This book constitutes a key reference on the use of algae in the BFs production field; providing an updated outlook on the achievements accomplished thus far and transmitting a prospective view for this biotechnological application.

This book provides a detailed description of the technology as well as an updated outlook of the strides achieved thus far in the field of algae-based biopharmaceuticals. Algae constitute attractive expression hosts for the production of recombinant proteins with medical applications. Among the features that make them attractive candidates are: low cost, fast growth, wide biosynthetic capacity, and absence of human pathogens; which constitute substantial advantages with respect to bacterial and mammalian systems.

First, the features of algae as convenient hosts for the production of BFs are analyzed in terms of production costs, biosynthetic capacity, and safety (Chapter 1). Second, the genetic engineering tools for algae-species are described. Nuclear and chloroplast-based expression approaches are analyzed and compared in terms of biosynthetic advantages, gene expression complexity, and DNA transfer approaches (Chapter 2). In the following sections, chapters 3 to 7, the state of the art on producing distinct types of BFs in algae species is presented. Although this book is mainly focused on BFs, considering that the production of compounds with health-promoting properties are achieved using genetically-engineered algae strains, chapter 8 deals with nutraceuticals. In the ninth chapter, the developments reported thus far are placed in perspective and challenges for the field are discussed. Critical future prospects comprise the following: optimizing large-scale production in bioreactors, implementing glycoengineering approaches, optimizing nuclear expression, exploring new approaches for oral delivery, and implementing regulatory frameworks to accomplish technology transfer and regulatory approval of algae-made BFs.