Alcohol and the Liver

ISBN-13: 9781461341864 / Angielski / Miękka / 2012 / 406 str.

M. Fisher

Opis

Alcohol abuse is this culture's most important drug problem. Statistics indicate that it is exacting a great and relentlessly increasing toll of human suffering. It is clear that the problem is not being dealt with in any effective manner. At the invitation of the. Canadian Hepatic Foundation, many of the world's experts gathered in Toronto, May 14-15 1976, to focus attention on one of the most important aspects of the alcohol problem -alcohol induced liver damage. The epidemiology of alcohol induced liver disease was discussed and current views on the pathogenesis of the problem were reviewed. New insight into the pathological alterations of the liver was presented and some of our current therapeutic capabilities were discussed. Dr. Hans Popper summarized the Symposium and presented some of his views on those aspects of the problem which will require early attention by the research community. The Symposium achieved its immediate objective -that of bringing together the committed experts of various disciplines for an updating of our understanding of alcohol and the liver and for a discussion of new approaches to the problem. As a backdrop to the Symposium, however, was large writing on the wall to the effect that we are expending our research talents and efforts on a totally unnecessary problem. Right now we probably know enough and have sufficient resources at our disposal to solve the problem.

Spis treści

The Epidemiology of Cirrhosis of the Liver: A Statistical Analysis of Mortality Data with Special Reference to Canada.- Discussion.- Metabolism of Ethanol and the Effect of Ethanol on Metabolism.- The Role of Ethanol Metabolites in Hepatic Lipid Peroxidation.- Pyridine Nucleotides and Ethanol.- The Influence of Ethanol on Albumin Metabolism.- Mechanism of Induction by Ethanol of Hepatic Microsomal Drug-Metabolizing Enzymes.- Acceleration of Ethanol Metabolism by High Ethanol Concentrations and Chronic Ethanol Consumption: Role of the Microsomal Ethanol Oxidizing System (MEOS).- Discussion.- Metabolism of Ethanol and the Effects of Ethanol on Metabolism: General Discussion.- Organelle Pathology of Alcohol-Induced Hepatic Injury.- Discussion.- Pathogenesis of Alcoholic Liver Disease: An Overview.- Discussion.- Alcoholic Hepatitis.- Discussion.- The Pathogenesis of Alcoholic Cirrhosis.- Discussion.- Immune Mechanisms in Alcoholic Liver Disease.- Discussion.- Alcohol Induced Susceptibility to Hypoxic Liver Damage: Possible Role in the Pathogenesis of Alcoholic Liver Disease?.- Discussion.- The Natural History and Management of Alcoholic Liver Disease.- Discussion.- The Natural History and Management of the Patient with Alcoholic Liver Disease.- Discussion.- Summary of the Symposium and a Look Ahead.- Contributors.