Alcohol and Its Biomarkers : Clinical Aspects and Laboratory Determination

ISBN-13: 9780128003398 / Angielski / Twarda / 2015 / 312 str.

Dasgupta, Amitava

Opis

Alcohol and Its Biomarkers: Clinical Aspects and Laboratory Determination is a concise guide to all currently known alcohol biomarkers, their clinical application, and the laboratory methods used to detect them. Pathologists can use this resource to understand the limitations and cost factors associated with each method for determining certain alcohol biomarkers. In addition, interferences in these determinations are discussed, so that clinicians can understand the causes of falsely elevated biomarkers and pathologists and laboratory scientists can potentially eliminate them. The book focuses on the analytical methods used to detect alcohol in blood and urine, the limitations of alcohol determination using enzymatic methods, and the differences between clinical and forensic alcohol measurement. Chapters also cover cutting-edge alcohol biomarkers for potential use.

• Focuses on the analytical methods used for detecting alcohol in blood and urine along with the pitfalls and limitations of alcohol determination using enzymatic methods
• Explains the difference between clinical and forensic alcohol measurement
• Includes a brief overview of the benefits of consuming alcohol in moderation and the hazards of heavy drinking

Recenzje

"...a concise and well written book that delivers on its promise of presenting a comprehensive overview of alcohol and its biomarkers...a useful reference for health care professionals and laboratorians." --Lab Medicine

"...a concise and well written book that delivers on its promise of presenting a comprehensive overview of alcohol and its biomarkers...a useful reference for health care professionals and laboratorians." --Lab Medicine

Spis treści

1. Alcohol: Use, Abuse and Issues with Blood Alcohol Level
2. Genetic Aspect of Alcohol Metabolism and Drinking Behavior
3. Measurement of Alcohol Levels in Body Fluids and Transdermal Alcohol Sensors
4. Alcohol Biomarkers: An Overview
5. Liver Enzymes as Alcohol Biomarkers
6. Mean Corpuscular Volume, and Carbohydrate Deficient Transferrin as Alcohol Biomarker
7. Beta-hexosaminidase, Acetaldehyde-Protein Adducts and Dolichol as Alcohol Biomarkers
8. Direct Alcohol Biomarkers: Ethyl Glucuronide, Ethyl Sulfate, Fatty Acid Ethyl Esters and Phosphatidylethanol
9. Less commonly Used Alcohol Biomarkers and Proteomics in Alcohol Biomarker Discovery
10. Genetic Markers of Alcohol Use Disorder

O autorze

Dr. Amitava Dasgupta received his Ph.D degree in Chemistry from Stanford University and received his medical training in Toxicology and Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School Of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. He is also the Director of Clinical Chemistry and Toxicology Laboratory of Memorial-Hermann Laboratory Services, the major clinical teaching hospital of the University of Texas. In addition, he is also the Medical Director of Memorial-TIRR Hospital laboratory services.

Dr. Dasgupta has published over 235 scientific papers and edited, co-edited, authored or co-authored 20 books including books published by Elsevier. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis. He lectures both nationally and internationally on drug and alcohol testing and acts as an expert witness for the State of Texas for alcohol and drug related criminal prosecutions.