Alcohol, Drugs of Abuse, and Immune Functions

ISBN-13: 9780849383120 / Angielski / Twarda / 1995 / 288 str.

Ronald R. Watson;¬Abar;¬Abar

Opis

Substance abusers are an immunocompromised population, vulnerable to a wide array of new and resurgent infectious diseases - in spite of modern treatment. For example, opportunistic infections like tuberculosis are the principal cause of morbidity and mortality in HIV positive patients. Alcohol- and drug-induced disorders are wide-ranging, gaining prominence as the spectrum of emerging diseases broadens.
Alcohol, Drugs of Abuse, and Immune Functions reviews the role of these immunosuppressants as cofactors in disease. It covers the basic biology and immunology of impairments to defense against infectious disease. Alcohol and drug use is consistently associated with immunosuppression, although it isn't known if it is the substance itself, a metabolite, or an indirect effect that alters disease resistance. This text explores the advances toward answering this question, examines alcohol in different settings, its relationship to important cells, and the effects it can have on vital organs such as the liver and the lungs.

Spis treści

Immunomodulation Associated with Depression and Stress, E.M. Levy and C. Chancellor-FreelandThe Effect of Alcohol on the Cellular Immune Function in Animals, C.J. Grossman, G. Roselle, and M. NienaberImmunomodulation by Alcohol in Mice, S.K. Ardestani and R.R. WatsonAlcohol and Infections of the Lung, G.A. Roselle, C.J. Grossman, M.A. Neinaber, and C.L. MendenhallT Cell Modulations in Human Alcoholics, R.T. CookAlcoholic Liver Disease, Malnutrition, and the Immune Response, A. ChedidModulation of Cytokine Production in Human Lymphoid and Myeloid Cells by Alcohol In Vitro, G. Szabo, P. Mandrekar, B. Verma, and D. CatalanoAlcohol, Endothelial Cells, and Immunity, P. Borgs, M.H. Witte, and C.L. WitteEffect of Prenatal Alcohol Exposure on Hypothalamic-Pituitary-Adrenal Function and Expression of Glucocorticoid-Regulated Genes, E. Redei, I. Halasz, and F. AirdAlcohol Metabolism and Its Toxicity: Role of Kupffer Cells and Free Radicals, R.G. Thurman, B.U. Bradford, K.T. Knecht, H.D. Connor, R.P. Mason, U. Adachi, M. Goto, C. Sullivan, and D.T. FormanDo Alcohol and Other Substances of Abuse Alter the Natural Evolution and Susceptibility to Human Immunodeficiency Virus-1 Infections? O. Bagastra, R.J. Pomerantz, and A. Kajdacsa-BallaAlcohol and ImmunomodulationDuring Murine Acquired Immunodeficiency Syndrome, Y. Wang, D.S. Huang, and R.R. WatsonDysregulation in Cytokine Production by Alcohol Consumption: A Cofactor in the Development of Murine Acquired Immunodeficiency Syndrome, Y. Wang and R.R. WatsonAlcohol Abuse as a Possible Cofactor in the Progression of Acquired Immune Deficiency Syndrome: Do Th-1 and Th-2 Helper T Cell Subsets Play a Role? D.A. CohenThe Role of Alcohol on Endocrine-Immune Interactions, Y. Wang and R.R. WatsonEffects of Cocaine on Certain Macrophage Functions, S.S. Lefkowitz, A. Vaz, and D.L. Lefkowitz

O autorze

Ronald R. Watson