Airways Smooth Muscle: Modelling the Asthmatic Response in Vivo

ISBN-13: 9783034898638 / Angielski / Miękka / 2011 / 300 str.

David Raeburn; Mark A. Giembycz

Opis

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

Spis treści

1. Measurement of Airways Smooth Muscle Responsiveness in Animals.- 2. Methods of Drug Administration to the Lung in Animals.- 3. PAF and Antigen-Induced Bronchial Hyperreactivity in Guinea Pigs.- 4. Antigen-Induced Bronchial Hyperreactivity in Rats.- 5. Ozone-Induced Bronchial Hyperreactivity.- 6. Virus-Induced Bronchial Hyperreactivity.- 7. The Rabbit Model of Asthma and the Late Asthmatic Response.- 8. The Sheep as a Model of the Late Asthmatic Response.- 9. Primate Models of Asthma.- 10. The Sensitized Pig Model of Asthma.- 11. Transgenic Animals and the Modelling of Asthma.